Determinants and prognostic implication of periprocedural myocardial injury after successful recanalization of coronary chronic total occlusion

Autor: Luís Paiva, Luís Graça-Santos, Lino Gonçalves, Joana Delgado-Silva, Cristina Neves, Marco Costa, Elisabete Jorge, Francisco Soares
Rok vydání: 2020
Předmět:
Zdroj: Cardiovascular Intervention and Therapeutics. 36:470-480
ISSN: 1868-4297
1868-4300
Popis: Periprocedural myocardial injury (PMI) has been generally associated with major adverse cardiac events (MACE), however, limited studies addressed its clinical implications following chronic total occlusion (CTO) percutaneous coronary intervention (PCI). To evaluate the determinants and prognostic implication of PMI following CTO-PCI. Retrospective single-centre study of 125 consecutive patients undergoing CTO-PCI was attempted between December 2013 and December 2017. Angiographic success was achieved in 115 patients (92.0%) and cTn-I values were obtained 12–24 h following PCI. PMI was defined as an elevation of cTn-I above 5 times the 99th-percentile upper reference limit. Baseline demographic, clinical, angiographic and procedural characteristics were compared. Multivariate analysis was performed to determine the predictors of PMI and the correlates of PMI and 1-year MACE, a composite of all-cause death, non-fatal myocardial infarction, and target lesion revascularization. Overall, mean age was 67 ± 17 years; 25 patients (21.7%) were female; and PMI occurred in 41 patients (35.7%). Multivessel coronary artery disease (MVD) (odds ratio [OR], 3.41; 95% confidence interval [CI], 1.09–10.67; p = 0.04) and procedural complications (a composite of iatrogenic coronary artery dissection/haematoma or perforation) (OR, 19.08; 95% CI, 3.77–96.65; p
Databáze: OpenAIRE
Externí odkaz: