Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation
| Autor: | David J. McDermitt, Karen M. Osorio, Hyun Nyun Woo, Song Eun Lee, Ying V. Zhang, Tudorita Tumbar, Sanjeev K. Waghmare |
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| Rok vydání: | 2008 |
| Předmět: |
Keratinocytes
Male medicine.medical_specialty Cellular differentiation Mice Transgenic Biology Colony-Forming Units Assay Mice Hair cycle hemic and lymphatic diseases Internal medicine medicine Animals Regeneration Molecular Biology Cell Proliferation Mice Knockout integumentary system Cell growth Cell Differentiation Cell biology Endothelial stem cell Mice Inbred C57BL Adult Stem Cells medicine.anatomical_structure Endocrinology Core Binding Factor Alpha 2 Subunit Gene Targeting Female Hair cell Stem cell Cell activation Hair Follicle Developmental Biology Adult stem cell |
| Zdroj: | Development (Cambridge, England). 135(6) |
| ISSN: | 0950-1991 |
| Popis: | Aml1/Runx1 controls developmental aspects of several tissues, is a master regulator of blood stem cells, and plays a role in leukemia. However, it is unclear whether it functions in tissue stem cells other than blood. Here, we have investigated the role of Runx1 in mouse hair follicle stem cells by conditional ablation in epithelial cells. Runx1 disruption affects hair follicle stem cell activation, but not their maintenance, proliferation or differentiation potential. Adult mutant mice exhibit impaired de novo production of hair shafts and all temporary hair cell lineages, owing to a prolonged quiescent phase of the first hair cycle. The lag of stem cell activity is reversed by skin injury. Our work suggests a degree of functional overlap in Runx1 regulation of blood and hair follicle stem cells at an equivalent time point in the development of these two tissues. |
| Databáze: | OpenAIRE |
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