Motor network degeneration in amyotrophic lateral sclerosis
| Autor: | Martijn P. van den Heuvel, Esther Verstraete, Leonard H. van den Berg, Jan H. Veldink, René C.W. Mandl, Hilleke E. Hulshoff Pol, Niels Blanken |
|---|---|
| Přispěvatelé: | Human genetics |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Central nervous system lcsh:Medicine Neurological Disorders/Neuromuscular Diseases Degeneration (medical) Biology Corpus callosum Neuroscience/Motor Systems Neuroimaging medicine Humans Amyotrophic lateral sclerosis lcsh:Science Aged Motor Neurons Multidisciplinary medicine.diagnostic_test Amyotrophic Lateral Sclerosis lcsh:R Radiology and Medical Imaging/Magnetic Resonance Imaging Brain Magnetic resonance imaging Middle Aged medicine.disease Neurological Disorders/Neuroimaging Magnetic Resonance Imaging Functional imaging medicine.anatomical_structure Case-Control Studies Disease Progression Female lcsh:Q Functional magnetic resonance imaging Neuroscience Research Article |
| Zdroj: | PLoS ONE, Vol 5, Iss 10, p e13664 (2010) PLoS ONE, 5(10):e13664. Public Library of Science PLoS ONE Verstraete, E, van den Heuvel, M P, Veldink, J H, Blanken, N, Mandl, R C, Pol, H E H & van den Berg, L H 2010, ' Motor network degeneration in amyotrophic lateral sclerosis : A structural and functional connectivity study ', PLoS ONE, vol. 5, no. 10, e13664 . https://doi.org/10.1371/journal.pone.0013664 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0013664 |
| Popis: | Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by motor neuron degeneration. How this disease affects the central motor network is largely unknown. Here, we combined for the first time structural and functional imaging measures on the motor network in patients with ALS and healthy controls. Methodology/Principal Findings: Structural measures included whole brain cortical thickness and diffusion tensor imaging (DTI) of crucial motor tracts. These structural measures were combined with functional connectivity analysis of the motor network based on resting state FMRI. Focal cortical thinning was observed in the primary motor area in patients with ALS compared to controls and was found to correlate with disease progression. DTI revealed reduced FA values in the corpus callosum and in the rostral part of the corticospinal tract. Overall functional organisation of the motor network was unchanged in patients with ALS compared to healthy controls, however the level of functional connectedness was significantly correlated with disease progression rate. Patients with increased connectedness appear to have a more progressive disease course. Conclusions/Significance: We demonstrate structural motor network deterioration in ALS with preserved functional connectivity measures. The positive correlation between functional connectedness of the motor network and disease progression rate could suggest spread of disease along functional connections of the motor network. |
| Databáze: | OpenAIRE |
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