Effects of volatile anesthetics on elastic stiffness in isometrically contracting ferret ventricular myocardium
| Autor: | Philippe R. Housmans, Anna E. Bartunek, Victor Claes |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Methyl Ethers medicine.medical_specialty Economics Physiology Sevoflurane Contractility Sociology CrossBridge Isometric Contraction Physiology (medical) Internal medicine medicine Animals Ventricular Function Isoflurane Chemistry Osmolar Concentration Ferrets Cardiac muscle Stiffness Myocardial Contraction Elasticity medicine.anatomical_structure Anesthesia Anesthetics Inhalation Anesthetic Cardiology Calcium Human medicine medicine.symptom Halothane Extracellular Space medicine.drug |
| Zdroj: | Journal of applied physiology |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00841.2001 |
| Popis: | The effects of halothane, isoflurane, and sevoflurane on elastic stiffness, which reflects the degree of cross-bridge attachment, were studied in intact cardiac muscle. Electrically stimulated (0.25 Hz, 25°C), isometrically twitching right ventricular ferret papillary muscles ( n = 15) at optimal length ( L max) were subjected to sinusoidal length oscillations (40 Hz, 0.25– 0.50% of L maxpeak to peak). The amplitude and phase relationship with the resulting force oscillations was decomposed into elastic and viscous components of total stiffness in real time. Increasing extracellular Ca2+ concentration in the presence of anesthetics to produce peak force equal to control increased elastic stiffness during relaxation, which suggests a direct effect of halothane and sevoflurane on cross bridges. |
| Databáze: | OpenAIRE |
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