Effects of BCG and Corynebacterium parvum on the haemopoietic precursor cells in continuously irradiated mice: possible mechanisms of action in immunotherapy
| Autor: | N.M. Blackett, M.Y. Gordon, M. Aguado |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_treatment
Monocyte Spleen General Medicine Immunotherapy Biology Granulocyte medicine.disease Hematopoietic Stem Cells Mycobacterium bovis Microbiology Mice Inbred C57BL Mice medicine.anatomical_structure Bone Marrow Precursor cell medicine BCG Vaccine Neoplasm Animals Bone marrow Propionibacterium acnes Progenitor cell |
| Zdroj: | European journal of cancer. 13(3) |
| ISSN: | 0014-2964 |
| Popis: | Single or repeated administration of BCG or Corynebacterium Parvum (C. Parvum) to continuously irradiated mice resulted in increased numbers of haemopoietic precursor cells in their bone marrow and spleen. These cells were detected by their ability to form nodules in the spleen of irradiated transplanted recipients or monocyte/granulocyte colonies in agar diffusion chambers. This increase in haemopoietic progenitor cells did not, however, confer any advantage, in terms of survival when the mice were challenged with further doses of irradiation. The relevance of these findings to the available clinical data is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|