Long‐term follow‐up of patients with venous thromboembolism and COVID‐19: Analysis of risk factors for death and major bleeding

Autor:	Zichen Ji, Francisco Galeano-Valle, Javier de Miguel‐Díez, Lucía Ordieres-Ortega, Jorge del Toro-Cervera, Pablo Demelo-Rodríguez, Luis Álvarez-Sala-Walther
Rok vydání:	2021
Předmět:	Male medicine.medical_specialty Time Factors Coronavirus disease 2019 (COVID-19) Long term follow up venous thromboembolism Hemorrhage Risk Factors COVID‐19 Internal medicine Humans Medicine Prospective Studies cardiovascular diseases anticoagulation Pandemics Aged Cause of death Venous Thrombosis SARS-CoV-2 business.industry COVID-19 Cancer Original Articles Hematology General Medicine Middle Aged bleeding medicine.disease Icu admission Spain Female Original Article Observational study Pulmonary Embolism business Venous thromboembolism Major bleeding Follow-Up Studies SARS‐COV‐2
Zdroj:	European Journal of Haematology
ISSN:	1600-0609 0902-4441
Popis:	Introduction COVID‐19 predisposes patients to a higher risk of venous thromboembolism (VTE), although the extent of these implications is unclear and the risk of bleeding has been poorly evaluated. To date, no studies have reported long‐term outcomes of patients with COVID‐19 and VTE. Method Prospective observational study to evaluate long‐term (90 days or more) outcomes of patients diagnosed with VTE (PE, DVT of the extremities, or both) in the setting of COVID‐19. The main outcome of the study was a compound of major bleeding and death. Results The study comprised 100 patients (mean age 65 ± 13.9 years). At the time of VTE diagnosis, 66% patients were hospitalized, 34.8% of them in the ICU. Mean follow‐up was 97.9 ± 23.3 days. During the study period, 24% patients died and median time to death was 12 (IQR: 2.25‐20.75) days, 11% patients had major bleeding and median time to event was 12 (IQR: 5‐16) days. The cause of death was PE in 5% and bleeding in 2% of patients. There were no VTE recurrences. The main study outcome occurred in 29% patients. Risk of death or major bleeding was independently associated with ICU admission (HR 12.2; 95% CI 3.0‐48.3), thrombocytopenia (HR 4.5; 95% CI 1.2‐16.5), and cancer (HR 21.6; 95% CI 1.8‐259). Conclusion In patients with COVID‐19 and VTE, mortality and major bleeding were high and almost a third of deaths were VTE‐related. The majority of complications occurred in the first 30 days. ICU admission, thrombocytopenia, and cancer are risk factors for poor prognosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbeaadf666cfe8862819ac88caf0d8e4 https://doi.org/10.1111/ejh.13603 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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