ApoE phenotype is associated with inflammatory markers in middle-aged subjects
| Autor: | Anne Kunnari, O. Ukkola, Maarit Jokela, Markku Päivänsalo, Y. A. Kesäniemi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Apolipoprotein E medicine.medical_specialty Allergy Neurology Apolipoprotein B Immunology Inflammation Apolipoproteins E Internal medicine Humans Medicine Resistin Ultrasonography Pharmacology biology business.industry nutritional and metabolic diseases Middle Aged Atherosclerosis medicine.disease Phenotype Rheumatology C-Reactive Protein Endocrinology biology.protein Female lipids (amino acids peptides and proteins) medicine.symptom Tunica Intima Tunica Media business Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Inflammation Research. 58:54-59 |
| ISSN: | 1420-908X 1023-3830 |
| Popis: | Apolipoprotein (apo) E phenotype has been associated with inflammation markers. The determinants of these associations and the relationship between novel inflammation marker, resistin, and apoE phenotype are studied here.Middle-aged subjects of the population- based cohort (n = 526) of the OPERA- study were studied. Intima-media thickness (IMT) was measured with carotid ultrasound. The results suggest that, apoE phenotype was a significant independent predictive factor for resistin (p0.01) and hsCRP (p0.01) levels. The association of ApoE phenotype with hsCRP was seen among the subjects with the normal renal function (p = 0.005). ApoE4 was associated (p0.01) with the lowest hsCRP in the lowest IMT quartile while it's relation with the highest resistin levels was evident in the highest IMT quartile.ApoE phenotype is an independent determinant of plasma resistin and hsCRP levels. The extent of atherosclerosis and renal function seem to modify the effects of apoE phenotype on inflammatory parameters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink