Fourteen-Member Macrolides Suppress Interleukin-8 Production but Do Not Promote Apoptosis of Activated Neutrophils

Autor:	Shoichi Suzuki, Satoshi Omura, Yoshiko Tsuchihashi, Hiroyuki Yoshimine, Toshiaki Sunazuka, Tsuyoshi Nagatake, Atsushi Kumatori, Kouji Matsushima, Kazunori Oishi
Rok vydání:	2002
Předmět:	Lipopolysaccharides Programmed cell death Leupeptins Neutrophils Neutrophile medicine.medical_treatment Anti-Inflammatory Agents Apoptosis Cysteine Proteinase Inhibitors In Vitro Techniques Biology Dexamethasone Neutrophil Activation chemistry.chemical_compound medicine Humans Pharmacology (medical) Interleukin 8 Biologic Response Modifiers Antibacterial agent Pharmacology Interleukin-8 Leupeptin Biological activity Anti-Bacterial Agents Infectious Diseases Cytokine chemistry Immunology Cancer research Macrolides
Zdroj:	Antimicrobial Agents and Chemotherapy. 46:1101-1104
ISSN:	1098-6596 0066-4804
DOI:	10.1128/aac.46.4.1101-1104.2002
Popis:	A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest that 14-member macrolides achieve clinical efficacy for chronic airway diseases partly by suppressing IL-8 production by activated neutrophils, but not by enhancing apoptosis in these cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdf3bcd193b15edadfe7706b007fbfe https://doi.org/10.1128/aac.46.4.1101-1104.2002 Zobrazit plný text záznamu