Flabelliferins A and B, Sesterterpenoids from the South Pacific Sponge Carteriospongia flabellifera
| Autor: | Heidi R. Bokesch, Ranjala Ratnayake, Curtis J. Henrich, John A. Beutler, Thushara Diyabalanage, James B. McMahon, Kirk R. Gustafson, Tanya T. Ransom |
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| Rok vydání: | 2012 |
| Předmět: |
Sesterterpenes
Stereochemistry Oceans and Seas Carbon skeleton Pharmaceutical Science Antineoplastic Agents Article Analytical Chemistry Vanuatu Drug Discovery Flabelliferin B Animals Humans Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure biology Chemistry Organic Chemistry Absolute configuration Nuclear magnetic resonance spectroscopy biology.organism_classification Porifera Carteriospongia flabellifera Sponge Complementary and alternative medicine Molecular Medicine Flabellifera Drug Screening Assays Antitumor |
| Zdroj: | Journal of Natural Products. 75:1490-1494 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np3003518 |
| Popis: | Two new sesterterpenoids named flabelliferins A (1) and B (2) were isolated from the lipophilic extract of the sponge Cateriospongia flabellifera, collected in the South Pacific near Vanuatu. The structure and absolute configuration of these two compounds were assigned by a combination of one- and two-dimensional NMR spectroscopy and by Mosher's ester analysis. Flabelliferin A (1) has a rare 25-homocheilanthane carbon skeleton, while flabelliferin B (2) is a 24-nor-25-homoscalarane sesterterpenoid. |
| Databáze: | OpenAIRE |
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