| Autor: |
Patrick D'Silva, Prasenjit Prasad Saha, Vinaya Vishwanathan, Kondalarao Bankapalli |
| Přispěvatelé: |
Nilius, B, DeTombe, P, Gudermann, T, Jahn, R, Lill, R, Petersen, OH |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Reviews of Physiology, Biochemistry and Pharmacology ISBN: 9783319787732 |
| ISSN: |
2381-3652 |
| Popis: |
Iron-sulfur (Fe-S) clusters serve as a fundamental inorganic constituent of living cells ranging from bacteria to human. The importance of Fe-S clusters is underscored by their requirement as a co-factor for the functioning of different enzymes and proteins. The biogenesis of Fe-S cluster is a highly coordinated process which requires specialized cellular machinery. Presently, understanding of Fe-S cluster biogenesis in human draws meticulous attention since defects in the biogenesis process result in development of multiple diseases with unresolved solutions. Mitochondrion is the major cellular compartment of Fe-S cluster biogenesis, although cytosolic biogenesis machinery has been reported in eukaryotes, including in human. The core biogenesis pathway comprises two steps. The process initiates with the assembly of Fe-S cluster on a platform scaffold protein in the presence of iron and sulfur donor proteins. Subsequent process is the transfer and maturation of the cluster to a bonafide target protein. Human Fe-S cluster biogenesis machinery comprises the mitochondrial iron-sulfur cluster (ISC) assembly and export system along with the cytosolic Fe-S cluster assembly (CIA) machinery. Impairment in the Fe-S cluster machinery components results in cellular dysfunction leading to various mitochondrial pathophysiological consequences. The current review highlights recent developments and understanding in the domain of Fe-S cluster assembly biology in higher eukaryotes, particularly in human cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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