The epidemiological and radiographical characteristics of asymptomatic infections with the novel coronavirus (COVID-19): A systematic review and meta-analysis
| Autor: | Guo Tian, Dan-Feng Li, Xiaoxiao Liu, Danying Yan, Hong-Chao Liu, Shigui Yang, Xiaofang Fu, Lei Lan, Jie Wu, Chenyang Huang, Yuqing Zhou, Cheng Ding, Robert Hecht, Lanjuan Li, Changtai Zhu, Can Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty Coronavirus disease 2019 (COVID-19) 030106 microbiology Presymptomatic Review medicine.disease_cause Asymptomatic lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Epidemiology Covert infections medicine Humans lcsh:RC109-216 030212 general & internal medicine Viral shedding Asymptomatic Infections Coronavirus Epidemiological characteristics SARS-CoV-2 Transmission (medicine) business.industry COVID-19 General Medicine Confidence interval Virus Shedding Radiographical findings Infectious Diseases Meta-analysis Radiography Thoracic medicine.symptom business |
| Zdroj: | International Journal of Infectious Diseases International Journal of Infectious Diseases, Vol 104, Iss, Pp 458-464 (2021) |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2021.01.017 |
| Popis: | Objectives The role of asymptomatic infections in the transmission of COVID-19 have drawn considerable attention. Here, we performed a meta-analysis to summarize the epidemiological and radiographical characteristics of asymptomatic infections associated with COVID-19. Methods Data on the epidemiological and radiographical characteristics of asymptomatic infections were extracted from the existing literature. Pooled proportions with 95% confidence intervals were then calculated using a random effects model. Results A total of 104 studies involving 20,152 cases were included. The proportion of asymptomatic individuals among those with COVID-19 was 13.34% (10.86%–16.29%), among which presymptomatic and covert infections accounted for 7.64% (4.02%–14.04%) and 8.44% (5.12%–13.62%), respectively. The proportions of asymptomatic infections among infected children and healthcare workers were 32.24% (23.08%–42.13%) and 36.96% (18.51%–60.21%), respectively. The proportion of asymptomatic infections was significantly higher after 2020/02/29 than before (33.53% vs 10.19%) and in non-Asian regions than in Asia (28.76% vs 11.54%). The median viral shedding duration of asymptomatic infections was 14.14 days (11.25–17.04). A total of 47.62% (31.13%–72.87%) of asymptomatic infections showed lung abnormalities, especially ground-glass opacity (41.11% 19.7%–85.79%). Conclusions Asymptomatic infections were more commonly found in infected children and healthcare workers and increased after 2020/02/29 and in non-Asian regions. Chest radiographical imaging could be conducive to the early identification of asymptomatic infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|