Global Sensory Impairment Predicts Morbidity and Mortality in Older US Adults
| Autor: | William Dale, Camil Correia, Rachel C. Chen, Megan Huisingh-Scheetz, Kevin J. Lopez, Jayant M. Pinto, Martha K. McClintock, David W. Kern, Kristen Wroblewski, Philip Schumm |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Gerontology
Male Activities of daily living Poison control Article 03 medical and health sciences 0302 clinical medicine Weight loss Injury prevention Medicine Humans 030212 general & internal medicine Prospective Studies Geriatric Assessment Aged Aged 80 and over business.industry Montreal Cognitive Assessment Odds ratio Middle Aged Prognosis Confidence interval United States Sensation Disorders Female Geriatrics and Gerontology medicine.symptom Morbidity business Body mass index 030217 neurology & neurosurgery |
| Popis: | Objectives To evaluate global sensory impairment (GSI, an integrated measure of sensory dysfunction) as a predictor of physical function, cognition, overall health, and mortality. Design Prospective study. Setting The National Social Life, Health, and Aging Project. Participants A national probability sample of 3,005 home-dwelling older U.S. adults assessed at baseline (2005–06) and 5-year follow-up (2010–11). Measurements Gait speed, activity, disability, cognition, overall health, 5-year mortality. Results At baseline, older adults with worse GSI were slower (Timed Up and Go times: odds ratio (OR) = 1.32, 95% confidence interval (CI) = 1.17–1.50) and had more activity of daily living deficits (≥2: OR = 1.26, 95% CI = 1.10–1.46). Five years later, they were still slower (timed walk: OR = 1.22, 95% CI = 1.05–1.42), had more disabilities (≥2 instrumental activities of daily living; OR = 1.45, 95% CI = 1.23–1.70), were less active (daytime activity according to accelerometry: β = −2.7, 95% CI = −5.2 to −0.2), had worse cognitive function (Montreal Cognitive Assessment; β = −0.64, 95% CI = −0.84 to −0.44), more likely to have poorer overall health (OR = 1.16, 95% CI = 1.03–1.31) and lose weight (>10%: OR = 1.31, 95% CI = 1.04–1.64), and have died (OR = 1.45, 95% CI = 1.19–1.76). All analyses were adjusted for relevant confounders at baseline, including age, sex, race and ethnicity, education, smoking, problem drinking, body mass index, comorbidities, and cognitive function. Conclusion GSI predicts impaired physical function, cognitive dysfunction, significant weight loss, and mortality 5 years later in older U.S. adults. Multisensory evaluation may identify vulnerable individuals, offering the opportunity for early intervention to mitigate adverse outcomes. |
| Databáze: | OpenAIRE |
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