Intrinsic fertility of human oocytes
| Autor: | Tamotsu Kobayashi, Yuting Fan, Kazunori Shinohara, Noriyuki Yatabe, Naoki Aoyama, Helen Skaletsky, Keiichi Kato, Sherman J. Silber, Akiko Yabuuchi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Pregnancy Rate Cell Survival Natural cycle media_common.quotation_subject Fertility Single Embryo Transfer Biology 03 medical and health sciences Young Adult 0302 clinical medicine Age Distribution Japan Pregnancy medicine Humans media_common Retrospective Studies Gynecology 030219 obstetrics & reproductive medicine Outcome measures Obstetrics and Gynecology Large series Fertility Preservation Retrospective cohort study Middle Aged Oocyte Embryo Transfer 030104 developmental biology medicine.anatomical_structure Treatment Outcome Reproductive Medicine Oocytes Female Female partner Infertility Female |
| Zdroj: | Fertility and sterility. 107(5) |
| ISSN: | 1556-5653 |
| Popis: | Objective To study the intrinsic fertility of the human oocyte. Design A large retrospective study of natural cycle single embryo transfer (ET) IVF cycles. Setting Private IVF clinic, university, and private hospital. Patient(s) Patients were enrolled consecutively over an 8-year period in a single ET natural cycle protocol. Intervention(s) A total of 13,949 oocyte retrievals with natural IVF single ET. Software package R (version 3.2.5) was used for statistical calculations. Main Outcome Measure(s) Live baby rate per oocyte according to age. Result(s) A total of 14,185 natural cycle oocytes resulted in 1,913 live babies from single ET. The number of oocytes required to make one live baby in this large series varied with the age of the female partner. For those under 35, the live baby born per oocyte was 26%. For over age 42 it decreased to 1%. These results fit very robustly with a logistic function curve, which is at first steady (horizontal), followed by a linear decline after age 35 with a 10% loss every year until age 43, and then a flattening out (horizontal) by age 44. Conclusion(s) The intrinsic fertility per oocyte in natural cycle is far greater than reported in hyperstimulated cycles, varying robustly from 26% to 4% with age from |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|