Congenital skeletal malformations and cleft palate induced in goats by ingestion of Lupinus, Conium and Nicotiana species
Autor: | R.J. Callan, Thomas D. Bunch, Richard F. Keeler, Kip E. Panter |
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Rok vydání: | 1990 |
Předmět: |
Pyridines
ved/biology.organism_classification_rank.species Physiology Toxicology Anabasine Bone and Bones Tree tobacco Lupinus Conium Alkaloids Piperidines Pregnancy Tobacco medicine Animals Abnormalities Multiple Nicotiana Lupinus formosus Plant Poisoning Goat Diseases biology ved/biology Plant Extracts Goats Conium maculatum food and beverages Anatomy medicine.disease biology.organism_classification Palatoschisis Teratology Cleft Palate Plants Toxic Teratogens Female |
Zdroj: | Toxicon : official journal of the International Society on Toxinology. 28(12) |
ISSN: | 0041-0101 |
Popis: | K. E. Panter , R. F. Keeler , T. D. Bunch and R. J. Callan . Review article — Congenital skeletal malformations and cleft palate induced in goats by ingestion of Lupinus, Conium and Nicotiana species. Toxicon 28, 1377–1385, 1990.—Three piperidine alkaloid containing plants, Conium maculatum (poison-hemlock), Nicotiana glauca (tree tobacco) and Lupinus formosus (lunara lupine), induced multiple congenital contractures (MCC) and palatoschisis in goat kids when their dams were gavaged with the plant during gestation days 30–60. The skeletal abnormalities included fixed extension or flexure of the carpal, tarsal, and fetlock joints, scoliosis, lordosis, torticollis and rib cage abnormalities. Clinical signs of toxicity included those reported in sheep, cattle and pigs—ataxia, incoordination, muscular weakness, prostration and death. One quinolizidine alkaloid containing plant, Lupinus caudatus (tailcup lupine), on the other hand, which is also known to cause MCC in cows, caused only slight signs of toxicity in pregnant goats and no teratogenic effects in their offspring. |
Databáze: | OpenAIRE |
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