Analysis of side-effects of medium- and low-dose cyclosporin maintenance therapy in psoriasis
| Autor: | M.A. de Rie, Jan D. Bos, M. M. H. M. Meinardi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Time Factors Cyclosporins Dermatology Kidney Gastroenterology Drug Administration Schedule Nephrotoxicity Maintenance therapy Internal medicine Cyclosporin a Psoriasis medicine Humans Severe psoriasis Dose-Response Relationship Drug business.industry Low dose Middle Aged Alkaline Phosphatase medicine.disease Surgery Creatinine Hypertension Toxicity business |
| Zdroj: | British Journal of Dermatology. 123:347-353 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.1990.tb06295.x |
| Popis: | The side-effects of long-term cyclosporin A (CyA) treatment in 26 patients with severe psoriasis were evaluated. These patients had a mean PASI score of 30.2 and were treated with CyA for between 7 and 37 months (mean 19.5 months). There were three groups according to the dose of CyA, less than 2 mg/kg per day, 2-3 mg/kg per day and greater than 3 mg/kg per day. In all three groups, CyA was found to be equally effective. Treatment with CyA was discontinued in 12 of the 26 patients because of nephrotoxicity and/or development of hypertension. One was in the less than 2 mg/kg per day group, three were in the 2-3 mg/kg per day group and eight in the greater than 3 mg/kg per day group. There was no hepatotoxicity with CyA treatment. One patient developed two squamous cell carcinomas of the skin. |
| Databáze: | OpenAIRE |
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