Canine demodicosis: Hematological and biochemical alterations
| Autor: | Hitham Abdel-Saeed, R A Ghandour, Noha Y. Salem, Heba S. Farag |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
malondialdehyde
040301 veterinary sciences Veterinary medicine canine generalized demodicosis Physiology SF1-1100 C-reactive protein 0403 veterinary science chemistry.chemical_compound antioxidant enzymes SF600-1100 Demodicosis Medicine Blood urea nitrogen chemistry.chemical_classification Creatinine General Veterinary biology business.industry Glutathione peroxidase 0402 animal and dairy science Albumin 04 agricultural and veterinary sciences medicine.disease biology.organism_classification 040201 dairy & animal science Animal culture chemistry Alanine transaminase biology.protein total antioxidant capacity business Demodex Research Article |
| Zdroj: | Veterinary World Veterinary World, Vol 13, Iss 1, Pp 68-72 (2020) |
| ISSN: | 2231-0916 0972-8988 |
| DOI: | 10.14202/vetworld.2020.68-72 |
| Popis: | Background and Aim: One of the most common cutaneous infections seen in veterinary canine practice is canine demodicosis. Demodicosis is a parasitic skin infection with a possible impact on acute-phase proteins (APPs) and oxidant-antioxidant balance. This study aimed to estimate the possible alterations in hematological, biochemical, oxidant-antioxidant, and APP (C-reactive protein [CRP] and albumin) profiles in naturally infected dogs with demodicosis. Materials and Methods: This study enrolled 21 dogs that were divided into two groups: The control group including 7 apparently healthy dogs and the diseased group including 14 dogs with generalized demodicosis. Demodicosis was confirmed through microscopic detection. Blood samples were collected for the estimation of CBC, total protein, albumin, alanine transaminase, aspartate aminotransferase, blood urea nitrogen, creatinine, superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant capacity (TAC), catalase (CAT), malondialdehyde (MDA), and CRP levels. Results: Significant reduction in red blood cells along with significant elevation in white blood cells was recorded in the diseased group compared with the control group. There was also significant elevation in MDA, TAC, SOD, and CRP levels along with significant reduction in GSH-Px and CAT levels in the diseased group. Conclusion: Based on these findings, a relationship between canine generalized demodicosis and oxidant-antioxidant disequilibrium could be suggested. Evidence of this relation manifested in the elevation in MDA and SOD levels and reduction in GPx and CAT levels as a consequence to the release of ROS resulting from Demodex infection. CRP elevation is expected in canine demodicosis. |
| Databáze: | OpenAIRE |
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