Colloidal Porous AuAg Alloyed Nanoparticles for Enhanced Photoacoustic Imaging
| Autor: | Jung Gi Min, Woojin Lee, Yebin Jung, Suk Bong Hong, Jaehyoung Koo, Kimoon Kim, Eun-Yeong Park, Dong Hyun Lee, Doowon Choi, Chulhong Kim, Sungjee Kim |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Silver Surface Properties Analytical chemistry Nanoparticle Metal Nanoparticles 02 engineering and technology engineering.material 01 natural sciences 010309 optics Photoacoustic Techniques Colloid Mice Coating 0103 physical sciences Alloys Animals General Materials Science Colloids Particle Size Porosity Plasmon Mice Inbred BALB C 021001 nanoscience & nanotechnology engineering NIH 3T3 Cells Particle Nanorod Female Gold 0210 nano-technology Layer (electronics) |
| Zdroj: | ACS applied materialsinterfaces. 12(29) |
| ISSN: | 1944-8252 |
| Popis: | Colloidal porous AuAg alloyed nanoparticles (pAuAgNPs) were synthesized by galvanic replacement reaction from Ag nanocubes. pAuAgNPs have a 50 nm exterior diameter and half of their inner space consists of voids that have a bimodal size distribution with peaks at 21 and 8.3 nm. pAuAgNPs showed a plasmonic peak at 750 nm, which was exploited for photoacoustic (PA) imaging. Gold nanorods (AuNRs) were prepared and used as the control; they have a strong plasmonic peak at 720 nm. In in vitro experiments at respective plasmonic peak excitations, pAuAgNPs gave stronger PA signals than AuNRs by 8.9 times per particle and 11.7 times per dosage by exogenous atom. The high surface area per volume as a result of the inner voids amplified the PA signals by efficient thermoacoustic conversion. In experiments of chicken-tissue phantoms, pAuAgNPs showed PA signals through 4.5 cm thick tissue, whereas AuNRs gave no detectable signal. In whole-body in vivo experiments, pAuAgNPs injected into the body showed 2.7 times stronger PA signals than AuNRs. Coating the pAuAgNPs with a silica layer additionally increased their PA signal by 1.8 times when compared to the uncoated ones. |
| Databáze: | OpenAIRE |
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