The interaction effect of parental rejection and oxytocin receptor gene polymorphism on depression: a cross-cultural study in non-clinical samples
| Autor: | Vincenzo Paolo Senese, Kazuyuki Shinohara, Paola Venuti, Marc H. Bornstein, Vittorio Rosanio, Carla Nasti, Michelle Jin-Yee Neoh, Marzia Maresca, Gianluca Esposito |
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| Přispěvatelé: | School of Social Sciences, Senese, Vincenzo Paolo, Shinohara, Kazuyuki, Venuti, Paola, Bornstein, Marc H, Rosanio, Vittorio, Nasti, Carla, Neoh, Michelle Jin-Yee, Maresca, Marzia, Esposito, Gianluca |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male Cross-Cultural Comparison Adolescent Genotype Health Toxicology and Mutagenesis Oxytocin Polymorphism Single Nucleotide depression gene–environment interactions oxytocin interpersonal acceptance–rejection theory psychological adjustment Young Adult Genetic Psychology [Social sciences] Receptors Humans Polymorphism gene–environment interaction Polymorphism Genetic Depression Female Gene-Environment Interaction Receptors Oxytocin Public Health Environmental and Occupational Health Single Nucleotide Gene–Environment Interactions |
| Zdroj: | International Journal of Environmental Research and Public Health; Volume 19; Issue 9; Pages: 5566 |
| Popis: | Parental rejection has been consistently empirically implicated in a wide array of developmental, behavioural and psychological problems worldwide. However, the interaction effect between parental rejection in childhood and the oxytocin receptor genotype on psychological adjustment has yet to be investigated. The present study aimed to investigate gene–environment interaction effects between parental rejection (maternal and paternal) and oxytocin receptor (OXTR) gene polymorphisms (rs53576 and rs2254298) on depressive symptoms in adults in different cultural contexts. Adults from Italy and Japan (N = 133, age = 18–27 years, females = 68) were preliminarily genotyped and then completed the Parental Acceptance-Rejection Questionnaire for mothers and fathers and the Beck Depression Inventory. Hierarchical multiple regression analysis showed that paternal rejection was related to self-reported depression and that the effect of parental rejection was moderated by OXTR gene polymorphisms and nationality. Among Italians, OXTR rs2254298 A-carriers showed resilience to negative early parental care, whereas among Japanese, OXTR rs53576 non-A-carriers showed resistance to negative early paternal care. These findings align with expected relations between perceived acceptance–rejection and an individual’s psychological adjustment, as proposed by interpersonal acceptance–rejection theory, and indicate the need for future studies adopting a multicultural and multilevel approach to better understand how the effects of parental rejection extend into adulthood. |
| Databáze: | OpenAIRE |
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