Effectiveness of combined eccentric and concentric exercise over traditional cardiac exercise rehabilitation programme in patients with chronic heart failure: protocol for a randomised controlled study
| Autor: | Guillaume Plaquevent-Hostache, Romain Eschalier, Hélène Perrault, Guillaume Clerfond, Marie-Claire D'Agrosa Boiteux, Andreea Moisa, Christine Cuenin, Ruddy Richard, Frédéric Costes, Bruno Pereira, Julianne Touron |
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| Přispěvatelé: | Clinique Médicale Cardio-Pneumologie de Durtol, Cardiologie, Hôpital Privé Jacques Cartier [Massy], Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Médecine du Sport et Explorations Fonctionnelles, CHU Clermont-Ferrand, Faculty of Health Sciences, University of Ottawa [Ottawa], DRCI, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centre Hospitalier Universitaire de Clermont-Ferrand, University of Ottawa |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Cost-Benefit Analysis medicine.medical_treatment Walk Test 030204 cardiovascular system & hematology Rehabilitation Medicine 03 medical and health sciences 0302 clinical medicine Quality of life Protocol medicine Humans Eccentric Prospective Studies 030212 general & internal medicine Adverse effect Randomized Controlled Trials as Topic Heart Failure Protocol (science) Cardiac Rehabilitation Rehabilitation business.industry Resistance Training General Medicine medicine.disease Exercise Therapy 3. Good health Heart failure Quality of Life cardiac failure functional capacities Physical therapy Patient Compliance Calisthenics Ventilatory threshold business exercise training chronic disease [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | BMJ Open BMJ Open, BMJ Publishing Group, 2019, 9 (9), ⟨10.1136/bmjopen-2018-028749⟩ |
| ISSN: | 2044-6055 |
| DOI: | 10.1136/bmjopen-2018-028749 |
| Popis: | IntroductionExercise-based rehabilitation is a standard feature of chronic heart failure management. The effectiveness of eccentric exercise could offer new opportunities for better tailoring rehabilitation programme to patients’ limitations. The goal of the study is to contrast the impact of a mixed eccentric and concentric cycling training programme, to that of conventional concentric cycling rehabilitation in patients with chronic heart failure (peak oxygen consumption (VO2Peak) < 15 mL⋅kg-1⋅min-1, ejection fraction Methods and analysisIt is a prospective, open, controlled and randomised study (2×25 subjects) carried out in a single centre. Subjects will perform five exercise sessions per week per the randomisation outcome, with the intervention group performing eccentric in three of the five weekly sessions while the control group will perform the five sessions of concentric exercise. Cycling intensity will be the same in both groups and fixed to the power associated with the first ventilatory threshold. Self-management education programme, callisthenics sessions and muscle strength trainings will also be carried out as for any heart failure patient normally included in the rehabilitation programme. The primary outcome will be the change in distance covered during the 6 min walk test. Secondary outcomes will include other physical mobility parameters, functional exercise capacities, quality of life and body composition as well as skeletal muscle properties including mitochondrial function parameters.Ethics and disseminationThe study has been approved by the institutional ethics review board (17.079) and the French regulatory authority for research (2017-A00969-44). Adverse events that could occur during the protocol will be reported to the principal investigator. The results will be published in an international peer-reviewed journal.Trial registration numberNCT03716778. |
| Databáze: | OpenAIRE |
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