Taxane-based regimens as adjuvant treatment for breast cancer: a retrospective study in egyptian cancer patients
| Autor: | Noha Y. Ibrahim, Yasser Salah El Din Abdal-Kader, Michael Kheir Abdalmassih, Hamdy A. Azim, Mohamed Mahmoud Mousa, Raafat Ragaie Abdel Malek |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Anthracycline Epidemiology Receptor ErbB-2 Subgroup analysis Breast Neoplasms Docetaxel Disease-Free Survival Young Adult Breast cancer Median follow-up Internal medicine Antineoplastic Combined Chemotherapy Protocols Medicine Humans Anthracyclines Cyclophosphamide Survival analysis Aged Retrospective Studies Taxane business.industry Public Health Environmental and Occupational Health Cancer Retrospective cohort study Middle Aged medicine.disease Surgery Receptors Estrogen Chemotherapy Adjuvant Lymphatic Metastasis Egypt Female Taxoids business Receptors Progesterone |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(1) |
| ISSN: | 2476-762X |
| Popis: | Background: To evaluate the impact of adding taxanes to anthracycline-based regimens in the adjuvant setting in localized young female breast cancer patients on the overall survival (OS) and the disease free survival (DFS). Materials and Methods: This retrospective study included all female breast cancer patients who were candidates for adjuvant chemotherapy presenting to Kasr Al Ainy centre of clinical oncology and Cairo oncology centre (Cairo Cure) in the period from January 2005 till December 2010. Results: Our study included 865 patients, 732 of whom received anthracycline based regimens and 133 taxane based regimens. The mean age of patients was 39 years. After a median follow up of 50 months the median DFS was 48.4 months. Survival analysis indicated that the tumor size (>5cm vs. |
| Databáze: | OpenAIRE |
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