Effects of Indomethacin on Cerebral Hemodynamics at Rest and during Endotracheal Suctioning in Preterm Neonates
| Autor: | Chantepie A, Elie Saliba, Pourcelot L, F Gold, Autret E, Laugier J |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_treatment
Indomethacin Hemodynamics Suction Placebo medicine.artery Intubation Intratracheal Anterior cerebral artery Humans Medicine Ductus Arteriosus Patent Saline Rest (music) business.industry Endotracheal suctioning Infant Newborn General Medicine Cerebral Arteries Mean frequency Echocardiography Doppler Cerebral hemodynamics Cerebrovascular Circulation Anesthesia Pediatrics Perinatology and Child Health business Blood Flow Velocity Infant Premature |
| Zdroj: | Acta Paediatrica. 80:611-615 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1991.tb11918.x |
| Popis: | The effect of therapeutic doses of indomethacin versus placebo (saline) on cerebral hemodynamics was studied in nine mechanically ventilated preterm infants. Recordings were made at rest and during endotracheal suctioning. Indomethacin at a dose of 0.2 mg/kg body weight was infused over 5 min. Compared to placebo, there was a significant decrease in Doppler mean frequency in the anterior cerebral artery within minutes of starting the indomethacin infusion during the resting period after the first (p less than 0.01), second (p less than 0.001) and third (p less than 0.025) doses. This effect has persisted during endotracheal suctioning. Thus, indomethacin alters cerebral hemodynamics by decreasing Doppler mean frequency. In view of these findings, and particularly because of the alteration in the resting cerebral hemodynamics, the recommendation of prophylactic treatment with indomethacin remains questionable. |
| Databáze: | OpenAIRE |
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