Bleeding profile of women with cardiovascular risk factors using a drospirenone only pill with 4 mg over nine cycles compared to desogestrel 0.075 mg

Autor:	Pedro-Antonio Regidor, Santiago Palacios, Enrico Colli
Rok vydání:	2022
Předmět:	Adult Desogestrel Adolescent Endocrinology Diabetes and Metabolism Obstetrics and Gynecology Middle Aged Ethinyl Estradiol Contraceptives Oral Combined Young Adult Endocrinology Cardiovascular Diseases Heart Disease Risk Factors Risk Factors Humans Androstenes Female
Zdroj:	Gynecological Endocrinology. 38:333-338
ISSN:	1473-0766 0951-3590
DOI:	10.1080/09513590.2022.2046729
Popis:	Progestin-only pills are associated with irregular bleeding patterns, including amenorrhea. Desogestrel (DSG) 75 mcg, a pill that inhibits ovulation, shows poor cycle control that may harm acceptability and compliance. A Drospirenone (DRSP)-only pill was developed with 244 days of activeplacebo days every 28-day cycle to improve cycle control.A phase III study in healthy women aged 18 to 45 years was performed to compare the bleeding profile of women taking a DRSP versus DSG over nine cycles. 249 women were older35 years: 173 using DRSP and 73 DSG. 259 women had a BMI25 kg/mAge: During cycles 2-4, the mean number of unscheduled bleeding days and spotting was 8.1 (SD10.53) for DRSP and 20.1 (19.41) for DSG;These analyses show the improvement in the bleeding profile of women with specific cardiovascular risk factors using the DRSP only oral contraceptive product compared to DSG.ImplicationsAn improvement in the bleeding profile of women with specific cardiovascular risk factors like age35 years, BMI25kg/m
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6e880e3c3cfe463a829e03af8640a5 https://doi.org/10.1080/09513590.2022.2046729 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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