| Autor: |
Quiana C. Wilkerson-Vidal, Madushika Wimalarathne, Genoah Collins, James Gerard Wolfsberger, Amelia Clopp, Luis Mercado, Evann Fowler, Helen Gibson, Victoria McConnell, Sidney Martin, Emily C. Hunt, Bernhard Vogler, Sharifa T. Love-Rutledge |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Molecular and Cellular Endocrinology. 562:111837 |
| ISSN: |
0303-7207 |
| Popis: |
Prediabetes affects 1 in 3 American adults and is characterized by insulin resistance, insulin hypersecretion, and impaired glucose tolerance. Weanling LEW.1WR1 (1WR1) rats have increased blood insulin concentrations, so we hypothesized that young adult 1WR1 rats would develop impaired glucose tolerance due to the poor regulation of insulin. We monitored glucose tolerance, insulin tolerance, and weight gain for 10 weeks to assess if there was a decline in glucose processing over time. 1WR1 rats were significantly more glucose intolerant after 8 weeks. 1WR1 rats had increased body mass, yet abdominal fat mass was not significantly increased. Although the 1WR1 rats had increased circulating insulin and glucagon protein levels, 1WR1 rat beta cell area was significantly reduced. There may be underlying insulin resistance as evidenced by dysfunctional insulin regulation during fasting. Understanding the metabolic phenotype of this rat model can provide insight into the human pathophysiological changes that increase susceptibility to glucose intolerance and prediabetes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect