Diffusion and transmission of carbapenem-resistant Klebsiella pneumoniae in the medical and surgical wards of a university hospital in Milan, Italy
| Autor: | Pietro Olivieri, Matteo Rimoldi, Massimo Galli, Lucia Dolcetti, Anna Piol, Sara Giordana Rimoldi, Maria Rita Gismondo, Anna Lisa Ridolfo, Cristina Pagani, Andrea F. Marino |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pediatrics Carbapenem resistant Klebsiella pneumoniae Klebsiella pneumoniae Cross-transmission Active surveillance law.invention Hospitals University law Medicine Aged 80 and over Cross Infection biology Incidence (epidemiology) lcsh:Public aspects of medicine General Medicine Middle Aged University hospital Intensive care unit Anti-Bacterial Agents Infectious Diseases Transmission (mechanics) Italy Female Adult medicine.medical_specialty Multidrug-resistant agents Genotype 030106 microbiology lcsh:Infectious and parasitic diseases 03 medical and health sciences Young Adult Intensive care Drug Resistance Bacterial Humans lcsh:RC109-216 Aged Retrospective Studies business.industry Public health Public Health Environmental and Occupational Health lcsh:RA1-1270 biology.organism_classification Klebsiella Infections Active screening Carbapenems Carbapenem-resistant Klebsiella pneumoniae business Infections control measures |
| Zdroj: | Journal of Infection and Public Health, Vol 9, Iss 1, Pp 24-33 (2016) |
| ISSN: | 1876-0341 |
| Popis: | Summary: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is emerging as a public health problem worldwide. In Italy, a remarkable increase in CRKP cases has been reported since 2010. In this study, CRKP diffusion, distribution and in-hospital transmission trends were evaluated in a university hospital in Milan, Italy, from January 2012 to December 2013. Isolates from 63 newly detected CRKP-positive patients were genotyped, and possible transmission was determined by combining the molecular results with data concerning the patients’ admission and in-hospital transfers. Most of the cases (90.4%) were from general medical and surgery wards, and the remaining 9.6% were from the intensive care unit. Fifteen of the 46 hospital-associated cases (32.6%) were attributable to in-hospital transmission. After the introduction of targeted and hospital-wide control measures, the transmission index significantly decreased from 0.65 to 0.13 (p = 0.01). There was also a decrease in the overall nosocomial case incidence, from 0.37 to 0.17 per 1000 person-days (p = 0.07).Our findings indicate that the spread of CRKP in Northern Italy hospitals may go far beyond high-risk settings (i.e., intensive care units) and that strict surveillance should be extended to general areas of care. Keywords: Multidrug-resistant agents, Carbapenem-resistant Klebsiella pneumoniae, Cross-transmission, Infections control measures, Active surveillance, Active screening |
| Databáze: | OpenAIRE |
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