Cadmium Mobilizationin Vivoby Intraperitoneal or Oral Administration of Monoalkyl Esters ofmeso-2, 3-Dmercaptosuccinic Acid in the Mouse
| Autor: | Alayne B. Smith, Loretta M. Atkins, Pramod K. Singh, Mark M. Jones, Gale Gr |
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| Rok vydání: | 1992 |
| Předmět: |
Male
inorganic chemicals Stereochemistry Health Toxicology and Mutagenesis chemistry.chemical_element Mice Inbred Strains Cadmium chloride Toxicology Mice Structure-Activity Relationship chemistry.chemical_compound In vivo Oral administration medicine Animals Tissue Distribution Chelation Pharmacology Cadmium Sodium bicarbonate Aqueous solution Dose-Response Relationship Drug Esters chemistry Dimercaptosuccinic acid Succimer Nuclear chemistry medicine.drug |
| Zdroj: | Pharmacology & Toxicology. 70:336-343 |
| ISSN: | 1600-0773 0901-9928 |
| DOI: | 10.1111/j.1600-0773.1992.tb00483.x |
| Popis: | The relative activities of a series of nine monoalkyl esters of meso-2,3-dimercaptosuccinic acid have been examined as agents for the mobilization of cadmium from mice one week after intraperitoneal administration of cadmium chloride. Eight of these are newly synthetized; all are of the type ROOCCH(SH)CH(SH)COOH, were R = Me, MMDMS; R = C2H5, MEDMS; R = (CH2)2CH3, Mn-PDMS; R = CHMe2, Mi-PDMS; R = (CH2)3CH3, Mn-BDMS; R = CH2CHMe2, Mi-BDMS; R = (CH2)4CH3, Mn-ADMS; R = (CH2)2CHMe2, Mi-ADMS; and R = (CH2)5CH3, Mn-HDMS. All are soluble in dilute sodium bicarbonate solutions and can be administered as aqueous solutions. Cadmium mobilization data were collected on each compound using mice previously loaded with cadmium; the monoesters were administered at a level of 0.40 mmol/kg intraperitoneally daily for five days. Data on whole body cadmium mobilization indicated that the monoester with the isoamyl group was the most effective under the conditions used. The relative whole body cadmium mobilization increased with the number of carbon atoms in the alkyl group of the monoester up to C5 and then decreased for the C6 compound. Cadmium removal from the kidneys and liver was also measured. It was found that the monoisoamyl ester was the most effective in removing cadmium from both the liver and the kidneys. The monoisoamyl ester also proved to be very effective in mobilizing cadmium from both the liver and the kidneys when given orally. This is the first compound which is reported capable of mobilizing cadmium in vivo from aged deposits after oral administration. |
| Databáze: | OpenAIRE |
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