Insight into the Mammalian Aquaporin Interactome

Autor:	Susanna Törnroth-Horsefield, Clara Chivasso, Helin Strandberg, Claudia D’Agostino, Carla V. T. O’Neale, Kevin L. Schey, Christine Delporte
Rok vydání:	2022
Předmět:	Mammals Organic Chemistry Water Hydrogen Peroxide General Medicine Aquaporins Catalysis Computer Science Applications Inorganic Chemistry Animals Urea Physical and Theoretical Chemistry Molecular Biology Spectroscopy
Zdroj:	International journal of molecular sciences
ISSN:	1422-0067
DOI:	10.3390/ijms23179615
Popis:	Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living organisms. AQPs facilitate osmotically driven water flux across biological membranes and, in some cases, the movement of small molecules (such as glycerol, urea, CO2, NH3, H2O2). Protein–protein interactions play essential roles in protein regulation and function. This review provides a comprehensive overview of the current knowledge of the AQP interactomes and addresses the molecular basis and functional significance of these protein–protein interactions in health and diseases. Targeting AQP interactomes may offer new therapeutic avenues as targeting individual AQPs remains challenging despite intense efforts.
Databáze:	OpenAIRE
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