Amelioration by menadione of the experimental chronic immune arthritis in the rabbit
| Autor: | Andrew A. Pitsillides, S. M. Blake, J. Chayen, L. E. Glynn, Lucille Bitensky |
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| Rok vydání: | 1990 |
| Předmět: |
Vitamin K
Clinical Biochemistry Arthritis Inflammation Glucosephosphate Dehydrogenase Pharmacology Biology Biochemistry chemistry.chemical_compound Immune system Menadione Oral administration medicine Animals Glucose-6-phosphate dehydrogenase Lagomorpha Synovial Membrane Cell Biology General Medicine medicine.disease biology.organism_classification Arthritis Experimental Disease Models Animal chemistry Rheumatoid arthritis Immunology Female Rabbits medicine.symptom |
| Zdroj: | Cell Biochemistry and Function. 8:221-226 |
| ISSN: | 1099-0844 0263-6484 |
| Popis: | The immunological induction of arthritis in the knee of the rabbit is well established as a model for human rheumatoid arthritis. It has the special advantage of allowing the development of the condition, and the effect of disease-modifying agents, to be followed. Attention has been focussed on the activity of glucose 6-phosphate dehydrogenase in the synovial lining cells since the fourfold elevation of this activity was shown to be fundamental in the human condition. An equal elevation of this activity has now been demonstrated in the rabbit model. Furthermore, it has been shown that the oral administration of menadione decreases this activity towards normality with a concomitant decrease in the degree of inflammation. |
| Databáze: | OpenAIRE |
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