Prevalence of mucosal and cutaneous human papillomavirus in Moroccan breast cancer
| Autor: | Massimo Tommasino, Amal ElAmrani, Sandrine McKay-Chopin, Tarik Gheit, Marilys Corbex, Mustapha Benhessou, Mohammed El Mzibri, Souha Sahraoui, Meriem Khyatti, Mohammed Attaleb |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology pHR Probable/possible high-risk BC Breast cancer 0302 clinical medicine Breast cancer Prevalence Medicine Statistical analysis Skin Human papillomavirus 16 Human papillomavirus 18 Middle Aged HPV Human papillomavirus HR High-risk Hpv testing Morocco Infectious Diseases Cutaneous hpv 030220 oncology & carcinogenesis Female MFI Median Fluorescence Intensity Type-specific multiplex genotyping Adult medicine.medical_specialty Human papillomavirus Genotype Breast Neoplasms Inflammatory breast cancer Article lcsh:Infectious and parasitic diseases 03 medical and health sciences Virology Internal medicine Multiplex polymerase chain reaction Humans lcsh:RC109-216 IBC Inflammatory breast cancer Mucous Membrane TS-MPG Type-specific polymerase chain reaction bead-based multiplex genotyping business.industry Papillomavirus Infections IARC International Agency for Research on Cancer medicine.disease Highly sensitive 030104 developmental biology DNA Viral business Multiplex Polymerase Chain Reaction |
| Zdroj: | Papillomavirus Research Papillomavirus Research, Vol 5, Iss, Pp 150-155 (2018) |
| ISSN: | 2405-8521 |
| Popis: | Background: Due to recent technical improvements and some encouraging new results, there has been a resurgence of interest in the possibility that a substantial proportion of breast cancers (BCs) may be caused by viral infections, including Human papillomavirus (HPV). The aim of this study was to determine the prevalence of mucosal and cutaneous HPV in tumours from Moroccan BC patients. Materials and methods: Frozen tumours from 76 BC cases and 12 controls were evaluated for the presence of 62 HPV-types using highly sensitive assays that combine multiplex polymerase chain reaction and bead-based Luminex technology. Results: HPV DNA was found in 25.0% of BC tumours and only 8.3% of controls. Beta and gamma HPV types were found in 10.5% and 6.6% of BC tumours, respectively. High-risk mucosal types HPV16 and 18 were not detected in the subjects, but other probable/possible high-risk or high-risk -HPV types (HPV51, 52, 58, 59, and 66) were found in 5.3% of BC tumours. Statistical analysis showed no significant difference between, controls, BC cases and the inflammatory status (p > 0.05). Conclusion: HPV DNA was found 3 times as frequently in the BC tumours as in the controls. However, this difference requires confirmation in a larger sample. Keywords: Breast cancer, Human papillomavirus, Inflammatory breast cancer, Type-specific multiplex genotyping, Morocco |
| Databáze: | OpenAIRE |
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