Gender interaction of uric acid in the development of hypertension
| Autor: | Takashi Yokoo, Tatsuo Hosoya, Naoki Sugano, Satoru Kuriyama, Shinichiro Nishio, Yukio Maruyama |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Blood Pressure 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound Sex Factors 0302 clinical medicine Japan Risk Factors Internal medicine Internal Medicine medicine Humans Longitudinal Studies 030212 general & internal medicine Risk factor Aged Retrospective Studies business.industry Incidence General Medicine Middle Aged humanities Uric Acid chemistry Hypertension Cohort Uric acid Female business |
| Zdroj: | Clinical and Experimental Hypertension. 40:446-451 |
| ISSN: | 1525-6006 1064-1963 |
| DOI: | 10.1080/10641963.2017.1392556 |
| Popis: | The present study explored the gender interaction on the risk of uric acid in the new development of hypertension.A longitudinal retrospective cohort.A total of 5,807 individuals with an average age of 38 ± 7 years old were recruited. Individuals whose blood pressure rose more than 140/90mmHg or those who newly commenced antihypertensive treatment were defined as a new onset of hypertension. Cox regression analysis was employed for the analysis.During the 10-years follow-up, 42.8% of men and 22.2% of women had developed hypertension. Factors to predict the hypertension development were male gender, older age, higher BMI, higher uric acid, and higher mean blood pressure. An association between higher uric acid levels and higher incidence of hypertension remained statistically significant in women in a multivariate model adjusted for various clinical variables (Hazard ration (HR), 1.180; 95%CI, 1.018 to 1.369), whereas such association was not found in men (HR, 1.034; 95%CI, 0.994 to 1.075). The interaction between the two genders reached statistical significance (p for interaction = 0.007).Higher uric acid is associated with the incident hypertension in the both genders. Women are more susceptible to the development of hypertension than men. |
| Databáze: | OpenAIRE |
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