Biomarkers of splenic function in infants with sickle cell anemia: baseline data from the BABY HUG Trial
| Autor: | Scott T. Miller, Rathi V. Iyer, Russell E. Ware, Zora R. Rogers, Bea Files, Barry L. Shulkin, John H. Miller, Eglal Shalaby-Rana, Winfred C. Wang, Bruce W. Thompson, Zhaoyu Luo, Peter A. Lane, Stephen D. Dertinger |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Hemolytic anemia medicine.medical_specialty Pathology Clinical Trials and Observations Anemia Immunology Spleen Anemia Sickle Cell Biochemistry Gastroenterology White blood cell Internal medicine Fetal hemoglobin medicine Humans Hematology business.industry Infant Cell Biology medicine.disease Sickle cell anemia Erythrocyte Inclusions medicine.anatomical_structure Hemoglobinopathy Liver Erythrocyte Count Female business Biomarkers |
| Zdroj: | Blood. 117:2614-2617 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood-2010-04-278747 |
| Popis: | We evaluated spleen function in 193 children with sickle cell anemia 8 to 18 months of age by 99mTc sulfur-colloid liver-spleen scan and correlated results with clinical and laboratory parameters, including 2 splenic biomarkers: pitted cell counts (PIT) and quantitative Howell-Jolly bodies (HJB) enumerated by flow cytometry. Loss of splenic function began before 12 months of age in 86% of infants in association with lower total or fetal hemoglobin and higher white blood cell or reticulocyte counts, reinforcing the need for early diagnosis and diligent preventive care. PIT and HJB correlated well with each other and liver-spleen scan results. Previously described biomarker threshold values did define patients with abnormal splenic function, but our data suggest that normal spleen function is better predicted by PIT of ≤ 1.2% or HJB ≤ 55/106 red blood cells and absent function by PIT ≥ 4.5% or HJB ≥ 665/106. HJB is methodologically advantageous compared with PIT, but both are valid biomarkers of splenic function. This trial was registered at www.clinicaltrials.gov as #NCT00006400. |
| Databáze: | OpenAIRE |
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