Identification of a novel antigen-presenting cell population modulating antiinfluenza type 2 immunity
| Autor: | Eleanor N. Fish, Jae-Kwang Yoo, Carole L. Galligan, Carl Virtanen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
CD4-Positive T-Lymphocytes
Adoptive cell transfer T cell Immunology Orthomyxoviridae Population Antigen-Presenting Cells medicine.disease_cause urologic and male genital diseases Virus Article 03 medical and health sciences Mice 0302 clinical medicine Cross-Priming Influenza A Virus H1N1 Subtype Th2 Cells Orthomyxoviridae Infections Immunity Cell Movement medicine Influenza A virus Immunology and Allergy Animals Antigen-presenting cell education Antigens Viral Lung 030304 developmental biology 0303 health sciences education.field_of_study Mice Inbred BALB C biology Gene Expression Profiling Cell Polarity biology.organism_classification Virology 3. Good health Mice Inbred C57BL Protein Transport medicine.anatomical_structure Phenotype Lymph Nodes 030215 immunology |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | Antiinfluenza type 2 (T2) immunity contributes to both immunopathology and immunoprotection, yet the underlying mechanisms modulating T2 immunity remain ill defined. We describe a novel mouse antigen (Ag)-presenting cell (APC), designated late-activator APC (LAPC). After pulmonary influenza A (H1N1) virus infection, LAPCs enter the lungs, capture viral Ag, and subsequently migrate to the draining lymph node (DLN) and spleen, with delayed kinetics relative to dendritic cells (DCs). In the DLN, influenza virus–activated LAPCs present Ag and selectively induce T helper type 2 (Th2) effector cell polarization by cell–cell contact–mediated modulation of GATA-3 expression. In adoptive transfer experiments, influenza virus–activated LAPCs augmented Th2 effector T cell responses in the DLN, increased production of circulating antiinfluenza immunoglobulin, and increased levels of T2 cytokines in bronchoalveolar lavage fluid in recipient influenza virus–infected mice. LAPC-recipient mice exhibited exacerbated pulmonary pathology, with delayed viral clearance and enhanced pulmonary eosinophilia. Collectively, our results identify and highlight the importance of LAPCs as immunomodulators of T2 immunity during influenza A virus infection. |
| Databáze: | OpenAIRE |
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