Analysis of the clinical characteristics, drug treatments and prognoses of 136 patients with coronavirus disease 2019

Autor: Yonggang Chen, Jun Wu, Jianguang Liu, Lin Zhao, Jili Zou, Qiu-Xiang Yang, Jie Jiang, Jinhu Wu, Hua-Jun Wu, Wei Zhang, Ling Xie
Rok vydání: 2020
Předmět:
Male
ARDS
Comorbidity
Review Article
Disease
030226 pharmacology & pharmacy
Procalcitonin
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Pharmacology (medical)
030212 general & internal medicine
Medicine
Chinese Traditional
Review Articles
clinical characteristics
Age Factors
drug treatment
Middle Aged
Prognosis
Treatment Outcome
Female
Coronavirus Infections
Adult
China
medicine.medical_specialty
Pneumonia
Viral
Antiviral Agents
coronavirus disease 2019
03 medical and health sciences
Internal medicine
Diabetes mellitus
medicine
Humans
Immunologic Factors
Lymphocyte Count
Glucocorticoids
Pandemics
Aged
Retrospective Studies
Pharmacology
Creatinine
business.industry
COVID-19
Retrospective cohort study
medicine.disease
chemistry
Concomitant
drug‐induced liver injury
business
Biomarkers
prognoses
Zdroj: Journal of Clinical Pharmacy and Therapeutics
ISSN: 1365-2710
0269-4727
DOI: 10.1111/jcpt.13170
Popis: What is known and objective Since the December 2019 discovery of several cases of coronavirus disease 2019 (COVID‐19) in Wuhan, China, the infection has spread worldwide. Our aim is to report on the clinical characteristics, treatments and prognoses of COVID‐19. Methods This was a retrospective, single‐centre, case series of 136 patients who were diagnosed with COVID‐19 at Wuhan Third Hospital in Wuhan, China, between 28 January 2020 and 12 February 2020. The clinical characteristics, laboratory tests, treatment features and prognoses were summarized. Results and discussion The 136 patients were divided into a moderate (M) group (n = 103, 75.7%) and a severe and critical (SC) group (n = 33, 24.3%). There were significant differences in the incidences of concomitant chronic medical illnesses (eg, hypertension, diabetes and cardiovascular disease), fever, dry cough and dyspnoea among the two groups (P
Elderly patients with chronic diseases are more likely to develop severe or critical COVID‐19 with multiple organ damage or systemic injuries. The improvement of LYM and CRP may be associated with the prognoses of COVID‐19.
Databáze: OpenAIRE
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