Abdominal surgery performed under general anesthesia increases somatostatin-like immunoreactivity in human serum
| Autor: | Erika Pintér, János Szolcsányi, Gábor Pozsgai, Andras Antal, József Németh |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
endocrine system Sensory Receptor Cells medicine.medical_treatment Anesthetics General Immunology Anti-Inflammatory Agents Radioimmunoassay Pain Hernia Inguinal Somatostatin-like immunoreactivity Feedback Endocrinology medicine Humans Hernia Aged Nerve Fibers Unmyelinated Endocrine and Autonomic Systems business.industry Abdominal Wall Nociceptors Middle Aged medicine.disease Sensory Nerve Endings Up-Regulation Nociception Somatostatin Neurology Cholecystectomy Laparoscopic Anesthesia Cholecystectomy Female business hormones hormone substitutes and hormone antagonists Abdominal surgery |
| Zdroj: | Neuroimmunomodulation. 15(3) |
| ISSN: | 1423-0216 |
| Popis: | Objective: It has been established in animals that somatostatin (SST) is released from pain-activated sensory nerve endings and exerts systemic antinociceptive and anti-inflammatory actions. The aim of this study was to investigate the changes of SST-like immunoreactivity (SST-LI) in human serum before, immediately after and 2 h after surgical operations. Methods: 25 patients were enrolled in the study. Laparoscopic cholecystectomy, abdominal wall hernia or inguinal hernia operations were performed under combined anesthesia. A 5-ml blood sample was drawn from each patient, the blood was centrifuged and the serum frozen. SST-LI was determined from the defrosted samples by radioimmunoassay. Results: Abdominal surgical operationsinduced a significant increase of SST-LI in the serum. 2 h later it was restored in the cases of laparoscopic interventions but still remained elevated after hernia surgeries. Conclusions: In this human study we showed for the first time that surgical interventions elevate the endogenous SST-LI in human serum. It is assumed that the released SST is derived from the activated sensory nerves. Since antinociceptive and anti-inflammatory effects of neural SST have already been established in laboratory animals, we presume that this endogenous protective mechanism also operates in humans. |
| Databáze: | OpenAIRE |
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