Zinc alleviates maneb-induced kidney injury in adult mice through modulation of oxidative stress, genotoxicity, and histopathological changes
| Autor: | Rim Marrekchi, Tahia Boudawara Sellami, Mediha Sefi, Awatef Elwej, Najiba Zeghal, Naourez Gouiaa, Kamel Jamoussi, Mhamed El Cafsi, Mariem Chaâbane, Safa Bejaoui, Nejla Soudani |
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| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
Health Toxicology and Mutagenesis medicine.medical_treatment Maneb 010501 environmental sciences Pharmacology Kidney medicine.disease_cause 01 natural sciences Antioxidants Nephrotoxicity Superoxide dismutase Mice Random Allocation chemistry.chemical_compound medicine Animals Environmental Chemistry 0105 earth and related environmental sciences chemistry.chemical_classification Glutathione Peroxidase biology Superoxide Dismutase Chemistry Glutathione peroxidase General Medicine Glutathione Malondialdehyde Pollution Oxidative Stress Zinc biology.protein Oxidative stress DNA Damage |
| Zdroj: | Environmental Science and Pollution Research. 27:8091-8102 |
| ISSN: | 1614-7499 0944-1344 |
| DOI: | 10.1007/s11356-019-07175-7 |
| Popis: | Zinc is one of the important essential trace minerals to human health due to its antioxidant properties. The present study was conducted to elucidate its potential protective role against maneb-induced nephrotoxicity. For this purpose, animals were randomly divided into four groups of six each. Mice of group I (negative controls) have received daily 0.5 ml of distilled water, a solvent of maneb. Mice of group II (MB) have received 30 mg/kg bw of maneb daily by intraperitoneal way. Mice of group III (MB + Zn) have received the same dose of maneb as group II, along with ZnSO4 (30 mg/kg bw) daily. Mice of group IV (Zn), considered as positive controls, have received the same dose of ZnSO4 as group III daily. Our results revealed that ZnSO4 co-administration to maneb-treated mice decreased kidney levels of malondialdehyde, hydrogen peroxide, protein carbonyls, and advanced oxidation protein products; the levels of non-enzymatic antioxidants like vitamin C, glutathione, and metallothionein. It recovered the alteration of antioxidant enzyme activities (catalase, superoxide dismutase, and glutathione peroxidase) and attenuated DNA fragmentation. Furthermore, this essential trace element was also able to alleviate kidney biomarkers’ alterations by lowering plasma levels of creatinine, urea, uric acid, and lactate dehydrogenase. In addition, the histopathological changes induced by maneb were improved following zinc administration. Our results indicated that zinc might be beneficial against maneb-induced renal oxidative damage in mice. |
| Databáze: | OpenAIRE |
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