Association of Left Atrial Myocardial Function With Left Ventricular Diastolic Dysfunction in Subjects With Preserved Systolic Function: A Strain Rate Imaging Study
| Autor: | Zhiqiang Guan, Fang Zhang, Qingrong Wang, Rongjie Huang, Di Zhang, Sheng-Lan Guo |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease Systole Clinical Investigations Diastole Doppler echocardiography Severity of Illness Index Ventricular Dysfunction Left Internal medicine Severity of illness Humans Medicine Heart Atria Ejection fraction medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Myocardial Contraction Echocardiography Doppler Strain rate imaging Circulatory system Cardiology Atrial Function Left Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Clinical Cardiology. 33:643-649 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.20784 |
| Popis: | Background: The purpose of this study was to investigate the relationship between left atrial (LA) myocardial function and left ventricular (LV) diastolic dysfunction in subjects with preserved LV ejection fraction (LVEF). Methods: The study included a group of 118 hypertensive patients and normal subjects. LV diastolic dysfunction was classified into 4 groups: none, mild, moderate, and severe. Peak strain rates in systole (S-Sr), early diastole (E-Sr), and late diastole (A-Sr) were obtained from Doppler-derived strain rate imaging to evaluate LA myocardial deformation. Results: No significant difference in LA dimension was observed in subjects with different degrees of LV diastolic dysfunction, although LA myocardial strain rate parameters were all significantly different across the 4 groups (all with P < 0.001). Compared with patients of normal diastolic function, the mild diastolic dysfunction group had significantly lower E-Sr (0.62 ± 0.18 s−1 vs 1.20 ± 0.38 s−1, P < 0.001) and S-Sr (0.78 ± 0.16 s−1 vs 0.94 ± 0.22 s−1, P < 0.001) but increased A-Sr (1.14 ± 0.29 s−1 vs 1.00 ± 0.23 s−1, P = 0.05). Conclusions: By using strain rate imaging, significant changes of LA deformation in response to different stages of LV diastolic dysfunction were detected in subjects with preserved LVEF. Quantification of LA myocardial function rather than LA size may have the potential to predict early LV diastolic dysfunction in subjects with preserved LVEF. Copyright © 2010 Wiley Periodicals, Inc. The authors have no funding, financial relationships, or conflicts of interest to disclose. |
| Databáze: | OpenAIRE |
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