Enantioselective synthesis of (R)- and (S)-3-methylspermidines
| Autor: | M. A. Khomutov, Janne Weisell, Sergey N. Kochetkov, Tuomo A. Keinänen, Jouko Vepsäläinen, Alex R. Khomutov, Mervi T. Hyvönen, Leena Alhonen |
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| Rok vydání: | 2015 |
| Předmět: |
Oxidoreductases Acting on CH-NH Group Donors
Molecular Structure biology Spermidine Stereochemistry Organic Chemistry Enantioselective synthesis Stereoisomerism Biochemistry Catalysis chemistry.chemical_compound Stereospecificity chemistry Cell Line Tumor biology.protein Humans Organic chemistry Deoxyhypusine synthase Bioorganic chemistry Enantiomeric excess |
| Zdroj: | Russian Journal of Bioorganic Chemistry. 41:548-553 |
| ISSN: | 1608-330X 1068-1620 |
| DOI: | 10.1134/s1068162015050064 |
| Popis: | Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity starting from commercially available R- and S-isomers of N-Boc-2-aminopropanol-1. Application of R- and S-isomers of 3-MeSpd for the investigation of the stereospecificity of spermidine transporter and peculiarities of deoxyhypusine synthase reaction are discussed. |
| Databáze: | OpenAIRE |
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