Poly(vinylbenzyl chloride) microsphere synthesis and their chemical modifications
| Autor: | G. Ponchel, A. Carpov, I. Dumistracel, D. Duchene, G. Danila |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Materials science
Polymers Drug Compounding Static Electricity Dispersity Pharmaceutical Science Infrared spectroscopy Capsules Bioengineering macromolecular substances Diffusion Excipients Surface-Active Agents chemistry.chemical_compound Colloid and Surface Chemistry Spectroscopy Fourier Transform Infrared Polymer chemistry Zeta potential Isoelectric Point Physical and Theoretical Chemistry Bovine serum albumin Fourier transform infrared spectroscopy Glucosamine biology Organic Chemistry technology industry and agriculture Povidone Serum Albumin Bovine Molecular Weight Polyvinyl chloride Freeze Drying Solubility Polymerization chemistry Pyrazines Attenuated total reflection biology.protein Polyvinyls |
| Zdroj: | Journal of Microencapsulation. 17:45-55 |
| ISSN: | 1464-5246 0265-2048 |
| DOI: | 10.1080/026520400288544 |
| Popis: | Vinylbenzyl chloride (VBC) was dispersion polymerized to give monodisperse microspheres in the presence of poly(vinylpyrrolidone) (PVP) as a steric stabilizer. The effect of PVP concentration on the size and on microsphere stability during the polymerization process was investigated. Microsphere size was examined when co-stabilizer molecules were employed with PVP during the polymerization reaction. The built-in reactive chloromethyl groups of the microspheres were the sites of the nucleophilic reaction of two amino-group model molecules, glucosamine (G), a hexosamine implicated in processes of molecular recognition, and also bovine serum albumin (BSA). Elemental analyses and Fourier transform infrared spectroscopy (FTIR) spectra showed that poly(vinylpyrrolidone) was associated with the microsphere network. Elemental analyses, attenuated total reflection infrared spectroscopy (ATR-FTIR), and zeta potential measurements confirmed G and BSA links at the microsphere surface. |
| Databáze: | OpenAIRE |
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