Clusters in Short-term Disease Course in Participants With Primary Dupuytren Disease
| Autor: | Rosanne Lanting, Paul M N Werker, Edwin R. van den Heuvel |
|---|---|
| Přispěvatelé: | Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Stochastic Operations Research, Statistics |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Dupuytren contracture PROGRESSION Disease 03 medical and health sciences 0302 clinical medicine disease progression NODULES Internal medicine medicine MANAGEMENT Humans Orthopedics and Sports Medicine 030212 general & internal medicine Prospective Studies Stage (cooking) Disease course Prospective cohort study Generalized estimating equation Aged Netherlands 030222 orthopedics Dupuytren disease business.industry Little finger disease regression Prognosis Regression Term (time) PREVALENCE medicine.anatomical_structure CONTRACTURE Physical therapy Surgery Female Contracture medicine.symptom business RADIOTHERAPY |
| Zdroj: | The Journal of Hand Surgery, 41(3), 354-361. W B SAUNDERS CO-ELSEVIER INC Journal of Hand Surgery, 41(3), 354-361. W.B. Saunders Ltd |
| ISSN: | 0363-5023 |
| Popis: | Purpose The course of Dupuytren disease (DD) is thought to be progressive; however, the course differs for each patient. The purpose of this study was to study the rate and pattern of progression of DD.Methods We prospectively analyzed the course of DD at intervals of 3 to 6 months in 247 Dutch participants with primary DD by measuring the surface area of nodules and cords and the total passive extension deficit. The association between surface area and Tubiana stage was tested with generalized estimating equations. Latent class models were used to study different clusters in changes regarding the course of the disease.Results The variance in disease course between participants was large. Regarding the change in surface area (in all fingers) and total passive extension deficit (in the ring and little finger), different clusters were observed. Progression of disease was seen but there were also signs of stability and even regression. Patients with a smaller surface area at baseline were more likely to exhibit regression.Conclusions This study showed that DD is not always progressive and that up to 75% of patients have a different short-term disease course, such as stability or even regression of disease. This should be taken into account when evaluating the effects of treatment for early-phase DD and in the design of future studies. Furthermore, this information may be useful when counseling patients. (Copyright (C) 2016 by the American Society for Surgery of the Hand. All rights reserved.) |
| Databáze: | OpenAIRE |
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