Longitudinal decline in lung function: evaluation of interleukin-10 genetic polymorphisms in firefighters
| Autor: | Walter T. Klimecki, Tracy A. Hysong, Maria A. Fierro, Jefferey L. Burgess, Eva Hnizdo, Richard Gerkin, R. Clark Lantz, Shannon M. Conley, Joy E. Fleming |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Genetic Markers Male Molecular Sequence Data Single-nucleotide polymorphism Polymerase Chain Reaction Risk Assessment Fires Cohort Studies Pulmonary Disease Chronic Obstructive Reference Values Forced Expiratory Volume Medicine SNP Humans Genotyping Lung function Occupational Health Probability Analysis of Variance Lung Polymorphism Genetic Base Sequence business.industry Incidence Significant difference Public Health Environmental and Occupational Health respiratory system Middle Aged respiratory tract diseases Interleukin-10 Respiratory Function Tests Occupational Diseases Interleukin 10 medicine.anatomical_structure Case-Control Studies Immunology Female business Follow-Up Studies |
| Zdroj: | Journal of occupational and environmental medicine. 46(10) |
| ISSN: | 1076-2752 |
| Popis: | During annual medical monitoring, some firefighters are found to have rates of decline in forced expiratory volume in one second (FEV 1 ) far exceeding their peers. Interleukin-10 (IL-10) suppresses inflammation, and single nucleotide polymorphisms (SNPs) in the IL-10 gene may confer variable susceptibility to more rapid decline in lung function. In 1204 firefighters with at least six annual FEV 1 measurements, increased age and greater initial FEV 1 were associated with more rapid decline in lung fraction. DNA collected from 379 of these firefighters was screened for IL-10 SNPs at -1117, -854, 919, 1668, and 1812. A statistically significant difference in decline in lung function was found based on genotyping at the 1668 SNP. Evaluation of gene polymorphisms regulating lung inflammation may help to explain some of the variation in rate of decline in lung function in firefighters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|