Source Localization and Possible Causes of Interictal Epileptic Activity in Tumor-Associated Epilepsy
| Autor: | Jens Fiehler, Jörg Steenbeck, Kristian Ebmeier, Stephan Patt, Ralf Huonker, Rudolf Hliscs, Nils Haberland, Albrecht Hochstetter, Robert Kraft, Jens Haueisen, Hannes Nowak, Rolf Kalff |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Patch-Clamp Techniques Action Potentials Electroencephalography Sodium Channels lcsh:RC321-571 Epilepsy In vivo Glioma Humans Medicine voltage-gated sodium channels Ictal lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Aged MEG medicine.diagnostic_test Brain Neoplasms business.industry Sodium channel Magnetoencephalography Magnetic resonance imaging Middle Aged patch-clamp medicine.disease Magnetic Resonance Imaging Electrophysiology Neurology brain tumors dipole source localization epilepsy Female business Neuroscience |
| Zdroj: | Neurobiology of Disease, Vol 7, Iss 4, Pp 260-269 (2000) |
| Popis: | Electrophysiological studies in gliomas have demonstrated action potentials in neoplastic cells. These "spiking tumor cells" are, however, an enigma. In attempt to find evidences for spikes within tumoral borders, 21 patients with different intracerebral tumors were preoperatively screened for the occurrence of epileptogenic discharges using multichannel MEG and EEG. A correlation between histopathology and the distance between dipole and tumor border could be found. Glioma patients showed epileptic activities closer to the border than those with mixed glioneuronal neoplasms and metastases. Four glioma patients demonstrated epileptic activity within the tumor boundary, however, not in the deep center of the tumor. Patch-clamping of cells from acute glioma slices did not yield a correlation between the presence of voltage-gated sodium channels in tumor cells and the MEG/EEG data. Our results demonstrate that the zone with the highest epileptogenic potential is different in gliomas and other brain tumors. However, our data do not strongly suggest that glioma cells are directly involved in the generation of tumor-associated epilepsy in vivo via their capability to generate action potentials. |
| Databáze: | OpenAIRE |
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