Inhibition of caffeine metabolism by 5‐methoxypsoralen in patients with psoriasis
| Autor: | Y. C. Bechtel, P Agache, Gilles Paintaud, P. Humbert, A Bendriss, J. Magnette, Bendriss Ek, P. R. Bechtel |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Urine chemistry.chemical_compound Oral administration Caffeine Internal medicine Psoriasis medicine Humans Pharmacology (medical) Aged Pharmacology Volume of distribution Chemistry Methoxsalen CYP1A2 Original Articles Middle Aged medicine.disease Endocrinology Toxicity 5-Methoxypsoralen Central Nervous System Stimulants Female medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 41:421-424 |
| ISSN: | 1365-2125 0306-5251 |
| DOI: | 10.1046/j.1365-2125.1996.33311.x |
| Popis: | Eight patients with psoriasis were given 200 mg caffeine orally with or without 1.2 mg kg-1 of 5-methoxypsoralen. Blood and urine samples were collected over a 2-day period. During 5-methoxypsoralen coadministration, the apparent volume of distribution of caffeine remained unchanged, but oral clearance (CLp.o.) decreased from 9.5 +/- 3.8 (mean +/- s.d.) to 3.2 +/- 0.51 h-1 (P < 0.01). The area under the plasma concentration-time curve (AUC) increased from 24 +/- 9 to 73 +/- 29 mg 1(-1) h (P < 0.001). This decrease in CLp.o. with increased AUC was consistent with a CYP1A2-dependent inhibition of caffeine N-demethylation which was further supported by significant decreases in the (AFMU+1U+1X)/17U and (AFMU+1U+1X)/17X urinary metabolic ratios. |
| Databáze: | OpenAIRE |
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