Lipoprotein(a) and coronary thrombosis and restenosis after stent placement
| Autor: | Adnan Kastrati, Albert Schömig, Hannsjörg Baum, Shpend Elezi, Siegmund Braun, Anne Wehinger, Franz-Josef Neumann |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Sensitivity and Specificity Coronary thrombosis Restenosis Recurrence Angioplasty Internal medicine Coronary stent medicine Humans Prospective Studies Angioplasty Balloon Coronary Prospective cohort study Aged biology business.industry Coronary Thrombosis Graft Occlusion Vascular Stent Lipoprotein(a) Middle Aged medicine.disease Surgery Treatment Outcome biology.protein Cardiology Female Stents business Cardiology and Cardiovascular Medicine Follow-Up Studies Lipoprotein |
| Zdroj: | Journal of the American College of Cardiology. 33(4):1005-1012 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/s0735-1097(98)00684-6 |
| Popis: | OBJECTIVES The objective of this prospective study was to evaluate the relation between high lipoprotein(a) levels and thrombotic and restenotic events after coronary stent implantation. BACKGROUND Lipoprotein(a) may promote atherogenesis, coronary thrombosis and restenosis after balloon angioplasty, but the clinical significance remains unclear. METHODS The study included 2,223 consecutive patients with successful coronary stent placement. According to the serum level of lipoprotein(a), patients were divided in two groups: 457 patients of the highest quintile formed the high lipoprotein(a) group, and 1,766 patients of the lower four quintiles formed the low lipoprotein(a) group. Primary end points were the incidence of angiographic restenosis at six months and the event-free survival at one year. Secondary end point was the incidence of angiographic stent occlusion. RESULTS Early stent occlusion occurred in four of the 457 patients (0.9%) with high and 37 of the 1,766 patients (2.1%) with low lipoprotein(a) levels, odds ratio of 0.41 (95% confidence interval, 0.15 to 1.16). Angiographic restenosis occurred in 173 of the 523 lesions (33.2%) in the high lipoprotein(a) group and 636 of the 1,943 lesions (32.7%) in the low lipoprotein(a) group, odds ratio of 1.02 (0.83 to 1.25). The probability of event-free survival was 73.0% in the high lipoprotein(a) group and 74.8% in the low lipoprotein(a) group (p = 0.45). On the basis of the findings in the low lipoprotein(a) group, the power of this study to detect a 25% increase in the incidence of restenosis and adverse events in the group with elevated lipoprotein(a) was 90% and 75%, respectively. CONCLUSIONS Elevated lipoprotein(a) levels did not influence the one-year clinical and angiographic outcome after stent placement. Thrombotic events and measures of restenosis were not adversely affected by the presence of high lipoprotein(a) levels. |
| Databáze: | OpenAIRE |
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