Urine neutrophil gelatinase‐associated lipocalin to diagnose and characterize acute kidney injury in dogs

Autor: Luca Magna, Mercedes Fernandez, Roberta Troia, Francesco Dondi, Massimo Giunti, C. Grisetti, Erika Monari, Marta Gruarin, Andrea Balboni
Přispěvatelé: Monari, Erika, Troìa, Roberta, Magna, Luca, Gruarin, Marta, Grisetti, Chiara, Fernandez, Mercede, Balboni, Andrea, Giunti, Massimo, Dondi, Francesco
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
040301 veterinary sciences
Urinary system
urine chemistry
Urology
Urine
Standard Article
030204 cardiovascular system & hematology
Lipocalin
Systemic inflammation
urologic and male genital diseases
intrinsic AKI
tubular damage
0403 veterinary science
Sepsis
03 medical and health sciences
0302 clinical medicine
Dogs
Lipocalin-2
medicine
Nephrology/Urology
Animals
Dog Diseases
Prospective Studies
Prospective cohort study
systemic inflammation
volume‐responsive AKI
lcsh:Veterinary medicine
General Veterinary
business.industry
urogenital system
Acute kidney injury
04 agricultural and veterinary sciences
medicine.disease
volume-responsive AKI
female genital diseases and pregnancy complications
Standard Articles
Case-Control Studies
lcsh:SF600-1100
Biomarker (medicine)
Female
Kidney Diseases
SMALL ANIMAL
medicine.symptom
business
Biomarkers
Zdroj: Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine, Vol 34, Iss 1, Pp 176-185 (2020)
ISSN: 1939-1676
0891-6640
Popis: Background Urine neutrophil gelatinase‐associated lipocalin (NGAL) is a promising biomarker of acute kidney injury (AKI) in dogs. Objectives To evaluate the utility of urinary NGAL for characterizing AKI according to volume responsiveness, presence of inflammation and sepsis, and prognosis. Animals Dogs with AKI (n = 76) and healthy controls (n = 10). Methods Prospective study. Clinical and clinicopathologic data including absolute urine NGAL concentration (uNGAL) and NGAL normalized to urine creatinine concentration (uNGALC) were measured upon admission. Dogs were graded according to International Renal Interest Society (IRIS) AKI guidelines and compared based on AKI features: volume‐responsive (VR‐) AKI vs. intrinsic (I‐) AKI based on IRIS criteria; VR‐AKI and I‐AKI based on urine chemistry; inflammatory versus noninflammatory; septic versus nonseptic; and survivors versus nonsurvivors. Nonparametric statistics were calculated, and significance set at P
Databáze: OpenAIRE
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