Amino acid alcohols: growth inhibition and induction of differentiated features in melanoma cells
| Autor: | Ofer Landau, Raphael Reiss, L. Wasserman, H. Panet, Abraham Novogrodsky, Jardena Nordenberg, Alexander A. Deutsch |
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| Rok vydání: | 1993 |
| Předmět: |
Cancer Research
Cellular differentiation Melanoma Experimental Biology Mice chemistry.chemical_compound Histidinol medicine Animals NADPH-Ferrihemoprotein Reductase chemistry.chemical_classification Cell growth Melanoma Biological activity gamma-Glutamyltransferase medicine.disease Amino Alcohols In vitro Amino acid Phenotype Oncology Biochemistry chemistry Enzyme Induction Growth inhibition Cell Division |
| Zdroj: | Cancer Letters. 69:203-208 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/0304-3835(93)90176-a |
| Popis: | The effects of a series of d - and l -amino acid alcohols on the proliferation and phenotypic expression of B16 mouse melanoma cells were evaluated. B16 melanoma cells were incubated for different time intervals in the presence of d - or l -phenylalaninol (PHE), d - or l -alaninol (AL), d - or l -leucinol (LE), l -histidinol (HIS), l -tyrosinol (TYR) and l -methioninol (MET). All agents, including the d or l configuration, induced an antiproliferative effect, although of considerably different magnitude. d -PHE was the most active growth inhibitor. The growth inhibitory effects were accompanied by phenotypic alterations, which included morphological changes and enhancement in the activities of NADPH cytochrome c reductase and τ-glutamyl transpeptidase. These phenotypic alterations correlated with the growth inhibitory effects of the different agents and seem to reflect a higher differentiated state. |
| Databáze: | OpenAIRE |
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