NDM-1 Hazard in the Balkan States: Evidence of the First Outbreak of NDM-1-Producing Klebsiella pneumoniae in Bulgaria
| Autor: | Elena Kioseva, Encho Savov, Lida Politi, Angelina Trifonova, Nicholas Spanakis, Athanasios Tsakris |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Genotype Klebsiella pneumoniae 030106 microbiology Immunology Gene Expression Microbial Sensitivity Tests Biology Microbiology beta-Lactam Resistance beta-Lactamases Disease Outbreaks 03 medical and health sciences Pulsed-field gel electrophoresis Humans Bulgaria Pharmacology Molecular screening Outbreak Klebsiella infections biology.organism_classification Virology Anti-Bacterial Agents Clone Cells Electrophoresis Gel Pulsed-Field Klebsiella Infections Carbapenems Multilocus sequence typing New delhi Multilocus Sequence Typing Plasmids |
| Zdroj: | Microbial drug resistance (Larchmont, N.Y.). 24(3) |
| ISSN: | 1931-8448 |
| Popis: | New Delhi MBL (NDM) carbapenemase-producing Klebsiella pneumoniae has become one of the most concerning multidrug-resistant pathogens. The Balkan counties are considered a reservoir for the spread of such strains based on several reports documenting NDM infections after hospitalization in this region. Nevertheless, NDM-producing K. pneumoniae have been only occasionally documented from Balkans. The current study documents the first polyclonal outbreak caused by NDM-1-producing K. pneumoniae in Bulgaria. From July 2015 to April 2016, all 25 single-patient carbapenem-nonsusceptible K. pneumoniae isolates were collected. Phenotypic and molecular screening revealed that 17 produced NDM-1 carbapenemase. All NDM-1 producers harbored blaCTX-M-15, blaCMY-4, blaTEM-1, and blaOXA-2; five also harbored blaOXA-1. In all cases, blaNDM-1 was flanked upstream by ISAba125 element and downstream by bleMBL. Pulsed-field gel electrophoresis (PFGE) clustered NDM-1-positive isolates into four distinct clonal types, A to D. ML... |
| Databáze: | OpenAIRE |
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