Role of 5-HT receptors in neuropathic pain: potential therapeutic implications
| Autor: | Rui Li, Ran Ji Cui, Wei Yang, Bing Jin Li, Shuo Hui Gao, Xiao Xiao Yao, Qian Qian Liu |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pain Threshold Serotonin Therapeutic action 03 medical and health sciences 0302 clinical medicine Serotonin Agents medicine Animals Humans Spinal nerve ligation Receptor 5-HT receptor Pharmacology Analgesics business.industry Spinal level Brain 030104 developmental biology medicine.anatomical_structure Spinal Cord 030220 oncology & carcinogenesis Peripheral nervous system Receptors Serotonin Neuropathic pain Neuralgia business Neuroscience Signal Transduction |
| Zdroj: | Pharmacological research. 159 |
| ISSN: | 1096-1186 |
| Popis: | 5-HT plays a crucial role in the progress and adjustment of pain both centrally and peripherally. The therapeutic action of the 5-HT receptors` agonist and antagonist in neuropathic pain have been widely reported in many studies. However, the specific roles of 5-HT subtype receptors have not been reviewed comprehensively. Therefore, we summarized the recent findings on multiple subtypes of 5-HT receptors in both central and peripheral nervous system in neuropathic pain, particularly, 5-HT1, 5-HT2, 5-HT3 and 5-HT7 receptors. In addition, 5-HT4, 5-HT5 and 5-HT6 receptors were also reviewed. Most of studies focused on the function of 5-HT subtype receptors in spinal level compared to brain areas. Based on these evidences, the pain process can be facilitated or inhibited that depending on the specific subtypes and the distribution of 5-HT receptors. Therefore, this review may provide potential therapeutic implications in treatment of neuropathic pain. |
| Databáze: | OpenAIRE |
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