The Role of Reactive Oxygen Species in Mitochondrial Permeability Transition
| Autor: | André R. Meinicke, Alicia J. Kowaltowski, Anibal E. Vercesi, Roger F. Castilho, Mercedes T. Grijalba |
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| Rok vydání: | 1997 |
| Předmět: |
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Molecular Biophysics Respiratory chain Mitochondrion Protein oxidation Biochemistry Permeability chemistry.chemical_compound Lipid oxidation Cardiolipin Animals Humans Submitochondrial particle Molecular Biology chemistry.chemical_classification Reactive oxygen species Intracellular Membranes Cell Biology Mitochondria Oxidative Stress chemistry Mitochondrial permeability transition pore Calcium Reactive Oxygen Species |
| Zdroj: | Bioscience Reports. 17:43-52 |
| ISSN: | 1573-4935 0144-8463 |
| DOI: | 10.1023/a:1027335217774 |
| Popis: | We have provided evidence that mitochondrial membrane permeability transition induced by inorganic phosphate, uncouplers or prooxidants such as t-butyl hydroperoxide and diamide is caused by a Ca2+-stimulated production of reactive oxygen species (ROS) by the respiratory chain, at the level of the coenzyme Q. The ROS attack to membrane protein thiols produces cross-linkage reactions, that may open membrane pores upon Ca2+ binding. Studies with submitochondrial particles have demonstrated that the binding of Ca2+ to these particles (possibly to cardiolipin) induces lipid lateral phase separation detected by electron paramagnetic resonance experiments exploying stearic acids spin labels. This condition leads to a disorganization of respiratory chain components, favoring ROS production and consequent protein and lipid oxidation. |
| Databáze: | OpenAIRE |
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