Study of Visceral and Subcutaneous Abdominal Fat Thickness and Its Correlation with Cardiometabolic Risk Factors and Hormonal Parameters in Polycystic Ovary Syndrome
| Autor: | Binoy Kumar Mohanty, Swayamsidha Mangaraj, Debarchan Jena, Arun Kumar Choudhury, Mamata Singh, Anoj Kumar Baliarsinha |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
obesity
medicine.drug_class Endocrinology Diabetes and Metabolism Physiology Adipose tissue 030209 endocrinology & metabolism Ovary lcsh:Diseases of the endocrine glands. Clinical endocrinology Androgen 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance insulin resistance medicine lcsh:RC799-869 visceral adipose tissue lcsh:RC648-665 030219 obstetrics & reproductive medicine highly sensitive C-reactive protein business.industry nutritional and metabolic diseases medicine.disease Obesity Polycystic ovary female genital diseases and pregnancy complications medicine.anatomical_structure polycystic ovary syndrome testosterone lcsh:Diseases of the digestive system. Gastroenterology Original Article business Body mass index Hormone |
| Zdroj: | Indian Journal of Endocrinology and Metabolism Indian Journal of Endocrinology and Metabolism, Vol 22, Iss 3, Pp 321-327 (2018) |
| ISSN: | 2230-8210 |
| Popis: | Aim of the Study: This study aimed to compare the different adiposity parameters, namely visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) between patients with polycystic ovary syndrome (PCOS) and controls. In addition, it aimed to correlate these adiposity indices with hormonal parameters as well as cardiovascular (CV) risk factors in patients with PCOS. Materials and Methods: Newly diagnosed PCOS patients of reproductive age group according to Rotterdam criteria were included. Age- and body mass index (BMI)-matched healthy females with normal menstrual cycles were taken as controls. All the study participants underwent detailed clinical, biochemical, and hormonal evaluation. Transabdominal ultrasound (US) was performed for detailed ovary imaging and assessment of adiposity (SAT and VAT) parameters. Results: A total of 58 PCOS patients and 40 age- and BMI-matched controls were included. PCOS patients had significantly higher levels of androgens (P < 0.001), elevated highly sensitive C-reactive protein (P = 0.007), and higher degree of insulin resistance (P < 0.001) than controls. PCOS patients had a mean SAT of 2.37 ± 0.7 cm and mean VAT of 8.65 ± 1.78 cm. These parameters were significantly higher than controls who had a mean SAT of 2.01 ± 0.7 cm (P = 0.014) and mean VAT of 7.4 ± 1.89 cm (P = 0.003), despite both groups having similar BMI. Among PCOS cohort, VAT correlated positively with total testosterone (r = 0.295, P = 0.025) and negatively with dehydroepiandrosterone sulfate (r = −0.210, P = 0.114). However, no significant correlation was observed between SAT and androgens in PCOS group. Conclusion: PCOS patients, whether obese or nonobese, had elevated visceral adiposity than controls. VAT correlated positively with adverse CV risk factors and testosterone in PCOS patients. Hence, a simple and inexpensive ultrasonography screening of visceral fat may identify women who have adverse metabolic profile and enhanced CV risk. |
| Databáze: | OpenAIRE |
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