Translational control in germline stem cell development
| Autor: | Ruth Lehmann, Maija Slaidina |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Cellular differentiation Gene regulatory network Reviews Review Biology Germline Mice Testis Animals Gene Regulatory Networks Genetics Ovary Robustness (evolution) Cell Differentiation Cell Biology biology.organism_classification Cell biology Adult Stem Cells Drosophila melanogaster Germ Cells Translational repression Protein Biosynthesis Female Stem cell Adult stem cell |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| DOI: | 10.1083/jcb.201407102 |
| Popis: | Stem cells give rise to tissues and organs during development and maintain their integrity during adulthood. They have the potential to self-renew or differentiate at each division. To ensure proper organ growth and homeostasis, self-renewal versus differentiation decisions need to be tightly controlled. Systematic genetic studies in Drosophila melanogaster are revealing extensive regulatory networks that control the switch between stem cell self-renewal and differentiation in the germline. These networks, which are based primarily on mutual translational repression, act via interlocked feedback loops to provide robustness to this important fate decision. |
| Databáze: | OpenAIRE |
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