An electronic alert system increases screening for hepatitis B and C and improves management of patients with haematological disorders
| Autor: | Paula Gubern, Luisa Roade, Maria Buti, Francesc Bosch, María José Carreras, Anna Farriols, Rafael Esteban, Pau Abrisqueta, Mar Riveiro-Barciela |
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| Přispěvatelé: | Institut Català de la Salut, [Riveiro-Barciela M, Esteban R, Buti M] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain. [Gubern P, Roade L] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Abrisqueta P, Bosch F] Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Carreras MJ, Farriols A] Servei de Farmàcia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Rok vydání: | 2020 |
| Předmět: |
Male
HBsAg medicine.medical_specialty Population lcsh:Medicine Article enfermedades hematológicas y linfáticas::enfermedades hematológicas [ENFERMEDADES] 03 medical and health sciences 0302 clinical medicine Electrònica mèdica Diagnòstic Internal medicine Prevalence medicine Humans Mass Screening disciplinas de las ciencias naturales::física::electrónica::electrónica médica [DISCIPLINAS Y OCUPACIONES] Diagnosis [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Medical prescription lcsh:Science education Alert system Mass screening education.field_of_study Multidisciplinary business.industry lcsh:R Hemic and Lymphatic Diseases::Hematologic Diseases [DISEASES] virus diseases Natural Science Disciplines::Physics::Electronics::Electronics Medical [DISCIPLINES AND OCCUPATIONS] diagnóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Middle Aged Hepatitis B medicine.disease Hepatitis C Hematologic Diseases digestive system diseases Electronics Medical 030220 oncology & carcinogenesis Sang - Malalties lcsh:Q Female Virus Activation 030211 gastroenterology & hepatology Viral hepatitis business Biomarkers Haematological disorders |
| Zdroj: | Scientific Reports Scientia Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-59476-4 |
| Popis: | Hepatitis B; Hepatitis C Hepatitis B; Hepatitis C Hepatitis B; Hepatitis C Treatment of haematological disorders in patients with chronic hepatitis B or resolved infection (anti-HBc-positive) is associated with a risk of hepatitis B reactivation. Moreover, patients with chronic hepatitis C have a higher risk of haematological malignancies than general population. An electronic alert system was developed to promote screening of hepatitis B (HBV) and C (HCV) in patients starting haematological therapies. The system included screening and linkage to care and a request for testing in those without data. From March, 2017 to March, 2018 data from 420 consecutive patients with haematological diseases were included. At first prescription before the alerts, the HCV and HBV screening rate was 60.5%. Following the alerts, an additional 115 were screened, increasing the overall screening rate to 87.9%. Anti-HBc alone was detected in 57, anti-HCV in 13, and HBsAg in 2 patients. Overall, 68% of patients with any viral hepatitis markers were previously not know, and the impact was particularly important for anti-HBc detection (47/57 unknown). Nucleoside analogues were prescribed in 28 (49.1%) anti-HBc-positive and the 2 HBsAg-positive patients. Prospective follow-up with HBV DNA and HBsAg testing showed no cases of HBV reactivation. An estimated 1.2 HBV reactivations were avoided as consequence of the alert system. In summary, an electronic alert system increased viral hepatitis screening in patients receiving haematological treatment and led to improvements in the management of these patients, including avoided HBV reactivation. This work was supported by a GoSHAPE European programme grant (Gilead Sciences Europe 2015).English language support was provided by Celine Cavallo. |
| Databáze: | OpenAIRE |
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